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Journal article
Roles of neuropathology-associated reactive astrocytes: a systematic review
Acta neuropathologica communications, v 11(1), pp 42-42
13 Mar 2023
PMID: 36915214
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
In the contexts of aging, injury, or neuroinflammation, activated microglia signaling with TNF-α, IL-1α, and C1q induces a neurotoxic astrocytic phenotype, classified as A1, A1-like, or neuroinflammatory reactive astrocytes. In contrast to typical astrocytes, which promote neuronal survival, support synapses, and maintain blood-brain barrier integrity, these reactive astrocytes downregulate supportive functions and begin to secrete neurotoxic factors, complement components like C3, and chemokines like CXCL10, which may facilitate recruitment of immune cells across the BBB into the CNS. The proportion of pro-inflammatory reactive astrocytes increases with age through associated microglia activation, and these pro-inflammatory reactive astrocytes are particularly abundant in neurodegenerative disorders. As the identification of astrocyte phenotypes progress, their molecular and cellular effects are characterized in a growing array of neuropathologies.
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Details
- Title
- Roles of neuropathology-associated reactive astrocytes: a systematic review
- Creators
- Jill M Lawrence - Drexel UniversityKayla Schardien - Drexel UniversityBrian Wigdahl - Drexel UniversityMichael R Nonnemacher - Drexel University
- Publication Details
- Acta neuropathologica communications, v 11(1), pp 42-42
- Publisher
- Springer BMC
- Grant note
- NS089435 / NINDS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000949397100001
- Scopus ID
- 2-s2.0-85150115784
- Other Identifier
- 991020206552904721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences