Journal article
Rural‐urban and racial/ethnic trends and disparities in early‐onset and average‐onset colorectal cancer
Cancer, v 127(2), pp 239-248
15 Jan 2021
PMID: 33112412
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background
Incidence rates (IRs) of early‐onset colorectal cancer (EOCRC) are increasing, whereas average‐onset colorectal cancer (AOCRC) rates are decreasing. However, rural‐urban and racial/ethnic differences in trends by age have not been explored. The objective of this study was to examine joint rural‐urban and racial/ethnic trends and disparities in EOCRC and AOCRC IRs.
Methods
Surveillance, Epidemiology, and End Results data on the incidence of EOCRC (age, 20‐49 years) and AOCRC (age, ≥50 years) were analyzed. Annual percent changes (APCs) in trends between 2000 and 2016 were calculated jointly by rurality and race/ethnicity. IRs and rate ratios were calculated for 2012‐2016 by rurality, race/ethnicity, sex, and subsite.
Results
EOCRC IRs increased 35% from 10.44 to 14.09 per 100,000 in rural populations (APC, 2.09; P < .05) and nearly 20% from 9.37 to 11.20 per 100,000 in urban populations (APC, 1.26; P < .05). AOCRC rates decreased among both rural and urban populations, but the magnitude of improvement was greater in urban populations. EOCRC increased among non‐Hispanic White (NHW) populations, although rural non‐Hispanic Black (NHB) trends were stable. Between 2012 and 2016, EOCRC IRs were higher among all rural populations in comparison with urban populations, including NHW, NHB, and American Indian/Alaska Native populations. By sex, rural NHB women had the highest EOCRC IRs across subgroup comparisons, and this was driven primarily by colon cancer IRs 62% higher than those of their urban peers.
Conclusions
EOCRC IRs increased in rural and urban populations, but the increase was greater in rural populations. NHB and American Indian/Alaska Native populations had particularly notable rural‐urban disparities. Future research should examine the etiology of these trends.
Rural populations have higher rates of colorectal cancer among individuals aged 20 to 49 years than urban populations, and these rates are increasing more quickly in rural populations; rates of colorectal cancer are highest in this age group among Black women and American Indian/Alaska Native men. Colorectal cancer rates are decreasing among those 50 years old or older in both rural and urban populations, but the improvement is better among urban populations.
Metrics
Details
- Title
- Rural‐urban and racial/ethnic trends and disparities in early‐onset and average‐onset colorectal cancer
- Creators
- Whitney E. Zahnd - University of South CarolinaScarlett L. Gomez - University of California, San FranciscoSusan E. Steck - University of South CarolinaMonique J. Brown - University of South CarolinaSabha Ganai - University of North DakotaJiajia Zhang - University of South CarolinaSwann Arp Adams - University of South CarolinaFranklin G. Berger - Pancreatic Cancer Action NetworkJan M. Eberth - University of South Carolina
- Publication Details
- Cancer, v 127(2), pp 239-248
- Publisher
- Wiley
- Number of pages
- 10
- Grant note
- American Cancer Society (MRSG‐15‐148‐01‐CPHPS) National Institute of Mental Health (K01MH115794) Federal Office of Rural Health Policy (U1CRH30539) Susan G. Komen for the Cure (GTDR 17500160)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Health Management and Policy
- Web of Science ID
- WOS:000583265800001
- Scopus ID
- 2-s2.0-85094161268
- Other Identifier
- 991021855180004721
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InCites Highlights
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Oncology