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SARS: lessons learned from other coronaviruses
Journal article   Peer reviewed

SARS: lessons learned from other coronaviruses

Sonia Navas-Martin and Susan R Weiss
Viral immunology, v 16(4), pp 461-474
2003
PMID: 14733734

Abstract

Rabbits Cats Coronavirus - classification Coronavirus - pathogenicity Humans Coronavirus Infections - physiopathology Rats Murine hepatitis virus - pathogenicity SARS Virus - pathogenicity Animals SARS Virus - genetics Coronavirus Infections - virology Cattle Dogs Coronavirus - genetics Mice Murine hepatitis virus - genetics Disease Models, Animal
The identification of a new coronavirus as the etiological agent of severe acute respiratory syndrome (SARS) has evoked much new interest in the molecular biology and pathogenesis of coronaviruses. This review summarizes present knowledge on coronavirus molecular biology and pathogenesis with particular emphasis on mouse hepatitis virus (MHV). MHV, a member of coronavirus group 2, is a natural pathogen of the mouse; MHV infection of the mouse is considered one of the best models for the study of demyelinating disease, such as multiple sclerosis, in humans. As a result of the SARS epidemic, coronaviruses can now be considered as emerging pathogens. Future research on SARS needs to be based on all the knowledge that coronavirologists have generated over more than 30 years of research.

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Web of Science research areas
Immunology
Virology
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