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Journal article
SF-36 summary and subscale scores are reliable outcomes of neuropsychiatric events in systemic lupus erythematosus
Annals of the rheumatic diseases, v 70(6), pp 961-967
01 Jun 2011
PMID: 21342917
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective To examine change in health-related quality of life in association with clinical outcomes of neuropsychiatric events in systemic lupus erythematosus (SLE). Methods An international study evaluated newly diagnosed SLE patients for neuropsychiatric events attributed to SLE and non-SLE causes. The outcome of events was determined by a physician-completed seven-point scale and compared with patient-completed Short Form 36 (SF-36) health survey questionnaires. Statistical analysis used linear mixed-effects regression models with patient-specific random effects. Results 274 patients (92% female; 68% Caucasian), from a cohort of 1400, had one or more neuropsychiatric event in which the interval between assessments was 12.3±2 months. The overall difference in change between visits in mental component summary (MCS) scores of the SF-36 was significant (p<0.0001) following adjustments for gender, ethnicity, centre and previous score. A consistent improvement in neuropsychiatric status (N=295) was associated with an increase in the mean (SD) adjusted MCS score of 3.66 (0.89) in SF-36 scores. Between paired visits when the neuropsychiatric status consistently deteriorated (N=30), the adjusted MCS score decreased by 4.00 (1.96). For the physical component summary scores the corresponding changes were +1.73 (0.71) and −0.62 (1.58) (p<0.05), respectively. Changes in SF-36 subscales were in the same direction (p<0.05; with the exception of role physical). Sensitivity analyses confirmed these findings. Adjustment for age, education, medications, SLE disease activity, organ damage, disease duration, attribution and characteristics of neuropsychiatric events did not substantially alter the results. Conclusion Changes in SF-36 summary and subscale scores, in particular those related to mental health, are strongly associated with the clinical outcome of neuropsychiatric events in SLE patients.
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Details
- Title
- SF-36 summary and subscale scores are reliable outcomes of neuropsychiatric events in systemic lupus erythematosus
- Creators
- J G Hanly - Nova Scotia Cancer CentreM B Urowitz - University of TorontoD Jackson - MRC Biostatistics UnitS C Bae - Hanyang University Seoul HospitalC Gordon - University of BirminghamD J Wallace - Cedars-Sinai Medical CenterA Clarke - Montreal General HospitalS Bernatsky - McGill University Health CentreA Vasudevan - SUNY Downstate Health Sciences UniversityD Isenberg - University College LondonA Rahman - University College LondonJ Sanchez-Guerrero - Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránJ Romero-Diaz - Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránJ T Merrill - Oklahoma Medical Research FoundationP R Fortin - Toronto Western HospitalD D Gladman - Toronto Western HospitalI N Bruce - University of ManchesterK Steinsson - Reykjavík UniversityM Khamashta - St Thomas' HospitalG S Alarcón - University of Alabama at BirminghamB Fessler - University of Alabama at BirminghamM Petri - Johns Hopkins UniversityS Manzi - University of PittsburghO Nived - Lund UniversityG Sturfelt - Lund UniversityR Ramsey-Goldman - Northwestern UniversityM A Dooley - University of North Carolina at Chapel HillC Aranow - Columbia University Irving Medical CenterR Van Vollenhoven - Karolinska InstitutetM Ramos-Casals - Hospital Clínic de BarcelonaA Zoma - Hairmyres HospitalK Kalunian - University of California, San DiegoV Farewell - MRC Biostatistics UnitSystemic Lupus Int Collaborating C
- Publication Details
- Annals of the rheumatic diseases, v 70(6), pp 961-967
- Publisher
- British Medical Journal (BMJ)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- General Internal Medicine
- Web of Science ID
- WOS:000290149900014
- Scopus ID
- 2-s2.0-79955863506
- Other Identifier
- 991021933898604721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Rheumatology