Journal article
SM-20, EGL-9, and the EGLN family of hypoxia-inducible factor prolyl hydroxylases
Molecules and cells, v 16(1), pp 1-12
31 Aug 2003
PMID: 14503838
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Key to the transduction of signals from the environment to the cell nucleus are enzymes that post-translationally modify proteins. Modifications such as protein phosphorylation have long been known to regulate protein interactions, stability, and localization, as well as enzyme activity. Recent investigations into how cells respond to varying oxygen levels have identified a new mechanism for regulating signal transduction involving the post-translational hydroxylation of proline. The enzymes that catalyze this reaction comprise a novel family of prolyl hydroxylases, which include a growth-factor-responsive and cell-death-related protein (SM-20) in mammals, and a protein (EGL-9) in C. elegans important for normal egg laying.
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Details
- Title
- SM-20, EGL-9, and the EGLN family of hypoxia-inducible factor prolyl hydroxylases
- Creators
- Robert S Freeman - University of RochesterDaphne M Hasbani - University of RochesterElizabeth A Lipscomb - University of RochesterJennifer A Straub - University of RochesterLiang Xie - University of Rochester
- Publication Details
- Molecules and cells, v 16(1), pp 1-12
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000185116000001
- Scopus ID
- 2-s2.0-1842627462
- Other Identifier
- 991021838142404721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biochemistry & Molecular Biology
- Cell Biology