Journal article
Safety and Efficacy of Brivaracetam in Pediatric Refractory Epilepsy: A Single-Center Clinical Experience
Journal of child neurology, v 35(2), pp 102-105
01 Feb 2020
PMID: 31617449
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Brivaracetam is a new antiepileptic drug with limited data in children. The objective of this study was to assess the efficacy/tolerability of brivaracetam. This is a retrospective chart review of children/adolescents with refractory epilepsy treated with brivaracetam from 2016 to 2018. The primary outcome was seizure reduction (decrease in seizure frequency >50%). Twenty-three patients were identified. Mean age at initiation was 12.5 years. Fourteen were females. Epilepsy was focal in 11, generalized in 6, and mixed in 3. Average dose was 3.9 mg/kg/d. The mean duration of treatment was 8.2 months. Eight had greater than 50% decrease in seizure frequency, of which 7 had focal epilepsy, and 1 had Lennox-Gastaut/mixed epilepsy. Two had drowsiness and 3 behavioral complaints. One experienced tingling and dizziness. Our retrospective review suggests that brivaracetam is an effective therapy for refractory focal epilepsy in children older than 4 years of age.
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Details
- Title
- Safety and Efficacy of Brivaracetam in Pediatric Refractory Epilepsy: A Single-Center Clinical Experience
- Creators
- Sara McGuire - St. Christopher's Hospital for ChildrenGustavo Silva - Hahnemann University HospitalDarshan Lal - Hahnemann University HospitalDivya S. Khurana - St. Christopher's Hospital for ChildrenAgustin Legido - St. Christopher's Hospital for ChildrenDaphne Hasbani - St. Christopher's Hospital for ChildrenKaren S. Carvalho - St. Christopher's Hospital for ChildrenJoseph Melvin - St. Christopher's Hospital for ChildrenIgnacio Valencia - St. Christopher's Hospital for Children
- Publication Details
- Journal of child neurology, v 35(2), pp 102-105
- Publisher
- Sage
- Number of pages
- 4
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000491460200001
- Scopus ID
- 2-s2.0-85074322439
- Other Identifier
- 991019169420604721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Clinical Neurology
- Pediatrics