Journal article
Safety and Efficacy of Ferric Carboxymaltose in Heart Failure with Preserved Ejection Fraction and Iron Deficiency
Current problems in cardiology, v 49(1), p102125
Jan 2024
PMID: 37806645
Abstract
Heart Failure with Preserved Ejection Fraction (HFpEF) is a prevalent cardiovascular condition characterized by a complex pathophysiology and limited therapeutic options. Coinciding iron deficiency often compounds the clinical picture, contributing to symptom burden and adverse outcomes. The review underscores the urgency for effective treatments in light of its increasing incidence and considerable healthcare burden. It highlights the clinical significance of addressing iron deficiency in HFpEF patients. FCM emerges as a promising therapeutic modality, demonstrating the ability to rapidly restore iron stores and enhance patients' quality of life while reducing hospitalization rates and mortality. The review thoroughly elucidates the impact of iron deficiency on HFpEF symptoms and outcomes, elucidating how FCM effectively mitigates these challenges. Detailed discussions encompass FCM's mechanism of action, pharmacokinetics, and safety profile. Notably, FCM's adaptability to diverse patient profiles and clinical settings is emphasized, reinforcing its clinical utility. Clinical evidence, including study designs, patient cohorts, and key findings, affirms FCM's potential as a valuable therapeutic option. Real-world data analysis further underscores FCM's practicality and safety beyond controlled clinical trials.The review concludes by addressing future research directions and critical research gaps, accentuating the need for mechanistic insights, long-term outcome studies, and refined patient selection criteria. As FCM increasingly integrates into clinical practice, it offers promise in revolutionizing HFpEF management, addressing an unmet need in this intricate cardiovascular condition.
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Details
- Title
- Safety and Efficacy of Ferric Carboxymaltose in Heart Failure with Preserved Ejection Fraction and Iron Deficiency
- Creators
- Hassan Shabeer - Armed Forces Institute of PathologyNaseer Samore - Armed Forces Institute of PathologySalman Ahsan - Department of Medicine, Shifa College of Medicine, Islamabad, PakistanMuhammad Umer Riaz Gondal - Reading HospitalBadar U Din Shah - Pakistan Institute of Medical SciencesAmna Ashraf - Department of Medicine, Millitary Hospital, Rawalpindi, PakistanMaria Faraz - Clínica Santa MaríaJahanzeb Malik - Department of Cardiovascular Medicine, Cardiovascular Analytics Group, Islamabad, Pakistan
- Publication Details
- Current problems in cardiology, v 49(1), p102125
- Publisher
- Elsevier Inc
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- General Internal Medicine
- Web of Science ID
- WOS:001125962100001
- Scopus ID
- 2-s2.0-85177783202
- Other Identifier
- 991022193967404721