Journal article
Safety and Efficacy of Universal Postoperative Decolonization for Kidney Transplant Recipients
Experimental and clinical transplantation, v 18(2), pp 153-156
01 Apr 2020
PMID: 31266440
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objectives: Infection is a common cause of morbidity and mortality after kidney transplant. Based on the well-documented successes of reducing infections with decolonization of patients in intensive care units, we began a universal immediate posttransplant decolonization program for all kidney transplant recipients. Herein, we report safety and efficacy of this decolonization program.
Materials and Methods: We compared a consecutive cohort of kidney transplant recipients who underwent universal decolonization (intervention group) with a cohort of transplant patients from an era immediately prior to this practice (control group). Universal decolonization included daily chlorhexidine body wash and nasal mupirocin ointment.
Results: Seventy-eight patients who underwent universal decolonization were compared with 43 patients in the control group. Ten microbiologically proven infections (8.3%) occurred in the 30 days after discharge: 7 (9%) in the intervention group and 3 (7%) in the control group. Forty-five transplant recipients (37.2%) were readmitted in the 30 days after discharge: 31 (39.7%) in the intervention group and 14 (32.6%) in the control group. No patients in the intervention group had adverse drug events from mupirocin and chlorhexidine use.
Conclusions: A universal decolonization protocol was successfully implemented and was well tolerated by all patients. Despite successful implementation, we did not observe any significant differences in infection rates between treated patients and historical controls.
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Details
- Title
- Safety and Efficacy of Universal Postoperative Decolonization for Kidney Transplant Recipients
- Creators
- Dong Heun Lee - Drexel UniversityGregory Malat - Drexel UniversitySuzanne M. Boyle - Drexel Univ, Div Nephrol, Coll Med, Philadelphia, PA 19104 USASindhura Talluri - Drexel Univ, Div Nephrol, Coll Med, Philadelphia, PA 19104 USATiffany E. Bias - Drexel Univ, Div Infect Dis & HIV Med, Coll Med, Philadelphia, PA 19104 USAMeera N. Harhay - Drexel Univ, Div Nephrol, Coll Med, Philadelphia, PA 19104 USAKarthik Ranganna - Drexel UniversityAlden Doyle - Drexel Univ, Div Nephrol, Coll Med, Philadelphia, PA 19104 USA
- Publication Details
- Experimental and clinical transplantation, v 18(2), pp 153-156
- Publisher
- Baskent Univ
- Number of pages
- 4
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Medicine (Graduate); College of Medicine; Surgery
- Web of Science ID
- WOS:000525736000005
- Scopus ID
- 2-s2.0-85083292655
- Other Identifier
- 991019168540704721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Transplantation