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Safety and efficacy of living donor liver preservation with HTK solution
Journal article   Peer reviewed

Safety and efficacy of living donor liver preservation with HTK solution

B Ringe, F Braun, M Moritz, G Zeldin, H Soriano and W Meyers
Transplantation proceedings, v 37(1), pp 316-319
Jan 2005
DOI: https://doi.org/10.1016/j.transproceed.2004.12.009
PMID: 15808629
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

Adolescent Adult Child Child, Preschool Female Glucose Hepatic Artery Humans Infant Liver Liver Transplantation - methods Liver Transplantation - mortality Liver Transplantation - physiology Living Donors Male Mannitol Middle Aged Organ Preservation - methods Organ Preservation Solutions Portal Vein Potassium Chloride Procaine Survival Analysis
In living donor liver transplantation (LDLTx) organ procurement is usually well controlled, and allows to assess liver preservation and graft function under standardized conditions. Because publications on histidine-tryptophan-ketoglutarate (HTK) solution are limited, we prospectively studied its safety and efficacy in a consecutive series of LDLTx. Twenty-four patients received 22 right, 1 left, and 1 left lateral lobe graft. Liver preservation was done by gravity perfusion with HTK through portal vein, and hepatic artery, and flushing of bile ducts. Total ischemia time was 191 +/- 68 minutes. There was no primary nonfunction, and all partial liver grafts showed good recovery: peak aspartate aminotransferase 577 U/L, total bilirubin 15.15 mg/dL, and partial thromboplastin time 49.37 seconds. One graft was lost from parenchymal fracture secondary to portal hyperperfusion after 6 days, and the patient was salvaged with retransplantation. Thirty-day mortality, including sudden cardiac death, pancreatitis, and hepatic artery rupture, was not related to graft dysfunction. Eight of 24 recipients developed early biliary leakage. There was no late ischemic type biliary lesion. These results confirm that HTK solution is safe and effective when used in LDLTx. Potential advantages of HTK in comparison to other preservation solutions are low potassium concentration, low viscosity, no particles, in situ perfusion, no need to flush before reperfusion, improved biliary protection, better recovery of microcirculatory changes, ready to use, and lower costs. Because the risk-benefit ratio is of particular importance in LDLTx the use of HTK solution should be encouraged.

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15 citations in Web of Science
18 citations in Scopus

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UN Sustainable Development Goals (SDGs)

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#3 Good Health and Well-Being

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Collaboration types
Domestic collaboration
International collaboration
Web of Science research areas
Immunology
Surgery
Transplantation
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