Journal article
Salicylic acid-releasing polyurethane acrylate polymers as anti-biofilm urological catheter coatings
Acta biomaterialia, v 8(5), pp 1869-1880
May 2012
PMID: 22342353
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Biofilm-associated infections are a major complication of implanted and indwelling medical devices like urological and venous catheters. They commonly persist even in the presence of an oral or intravenous antibiotic regimen, often resulting in chronic illness. We have developed a new approach to inhibiting biofilm growth on synthetic materials through controlled release of salicylic acid from a polymeric coating. Herein we report the synthesis and testing of a ultraviolet-cured polyurethane acrylate polymer composed, in part, of salicyl acrylate, which hydrolyzes upon exposure to aqueous conditions, releasing salicylic acid while leaving the polymer backbone intact. The salicylic acid release rate was tuned by adjusting the polymer composition. Anti-biofilm performance of the coatings was assessed under several biofilm forming conditions using a novel combination of the MBEC Assay™ biofilm multi-peg growth system and bioluminescence monitoring for live cell quantification. Films of the salicylic acid-releasing polymers were found to inhibit biofilm formation, as shown by bioluminescent and GFP reporter strains of Pseudomonas aeruginosa and Escherichia coli. Urinary catheters coated on their inner lumens with the salicylic acid-releasing polymer significantly reduced biofilm formation by E. coli for up to 5days under conditions that simulated physiological urine flow.
Metrics
Details
- Title
- Salicylic acid-releasing polyurethane acrylate polymers as anti-biofilm urological catheter coatings
- Creators
- Paul J Nowatzki - Bayer MaterialScience LLC, 100 Bayer Rd., Pittsburgh, PA, USARichard R Koepsel - McGowan Institute for Regenerative Medicine and Department of Surgery, University of Pittsburgh, 450 Technology Drive, Suite 300, Pittsburgh, PA 15219, USAPaul Stoodley - National Centre for Advanced Tribology at Southampton (nCATS), Faculty of Engineering and The Environment, University of Southampton, Southampton, UKKe Min - Bayer MaterialScience LLC, 100 Bayer Rd., Pittsburgh, PA, USAAlan Harper - The Center for Genomic Sciences, Allegheny-Singer Research Institute, Allegheny General Hospital, Pittsburgh, PA, USAHironobu Murata - McGowan Institute for Regenerative Medicine and Department of Surgery, University of Pittsburgh, 450 Technology Drive, Suite 300, Pittsburgh, PA 15219, USAJoseph Donfack - The Center for Genomic Sciences, Allegheny-Singer Research Institute, Allegheny General Hospital, Pittsburgh, PA, USAEdwin R Hortelano - Bayer MaterialScience LLC, 100 Bayer Rd., Pittsburgh, PA, USAGarth D Ehrlich - The Center for Genomic Sciences, Allegheny-Singer Research Institute, Allegheny General Hospital, Pittsburgh, PA, USAAlan J Russell - McGowan Institute for Regenerative Medicine and Department of Surgery, University of Pittsburgh, 450 Technology Drive, Suite 300, Pittsburgh, PA 15219, USA
- Publication Details
- Acta biomaterialia, v 8(5), pp 1869-1880
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000302989700021
- Scopus ID
- 2-s2.0-84859102518
- Other Identifier
- 991014877762704721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Industry collaboration
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Engineering, Biomedical
- Materials Science, Biomaterials