Journal article
Salvage With Revumenib: Targeting KMT2A‐Rearranged Isolated Leukemia Cutis Identified in the Extramedullary Disease
EJHaem, v 7(4), e70334
24 Jun 2026
PMID: 42359025
Abstract
Acute myeloid leukemia (AML) is an aggressive hematologic malignancy associated with a high risk of relapse. Leukemia cutis is characterized by the presence of neoplastic leukocytes infiltrating the skin. Here, we present a previously treated AML patient who relapsed with isolated leukemia cutis without bone marrow involvement. Fluorescence in situ hybridization (FISH) and RNA sequencing of the skin lesion revealed a KMT2A::MLLT6 rearrangement, which enabled the use of revumenib. This case highlights the diagnostic complexity and therapeutic implications of isolated extramedullary AML relapse and underscores the need to perform genetic testing at the site of disease recurrence—especially without bone marrow involvement of relapsed disease.
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Details
- Title
- Salvage With Revumenib: Targeting KMT2A‐Rearranged Isolated Leukemia Cutis Identified in the Extramedullary Disease
- Creators
- Bana Antonios - Allegheny Health NetworkXuemei Wu - Allegheny Health NetworkLynn Johnson - Allegheny Health NetworkAvani Ahuja - Allegheny Health NetworkMegan Blauvelt - Allegheny Health NetworkMargaret Aronckes - Allegheny Health NetworkNina Dutton - Allegheny Health NetworkJennifer Dujmic - Allegheny Health NetworkSalman Fazal - Allegheny Health NetworkTaimoor I. Sheikh (Corresponding Author) - Allegheny Health Network
- Publication Details
- EJHaem, v 7(4), e70334
- Publisher
- Wiley
- Number of pages
- 5
- Grant note
- Research Special Purpose Fund of the Department of Pathology, Allegheny Health Network
This study was supported by the Research Special Purpose Fund of the Department of Pathology, Allegheny Health Network.
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pathology (and Laboratory Medicine)
- Web of Science ID
- WOS:001800950600001
- Other Identifier
- 991022193896804721