Journal article
Sarcoidosis triggered by interferon-Beta treatment of multiple sclerosis: a case report and focused literature review
Seminars in arthritis and rheumatism, v 42(2), pp 206-212
01 Oct 2012
PMID: 22572392
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
To report a rare case of sarcoidosis induced by chronic interferon-beta (a type I interferon) therapy of multiple sclerosis and to review previously reported cases.
We describe a patient with a prior diagnosis of multiple sclerosis, who developed noncaseating granulomas in her skin and pulmonary lymph nodes, consistent with sarcoidosis, while being treated with recombinant interferon-beta. A retrospective review of the literature was performed using the PubMed database.
In our patient, sarcoidosis developed after 3 years of continuous recombinant interferon-beta therapy, dosed 3 times a week. The patient presented with progressive dyspnea on exertion, diffuse arthralgias, low-grade fevers, with an acute onset of rash. The diagnosis of sarcoidosis was secured by finding typical, well-formed, noncaseating granulomas on skin and endobronchial biopsies, with other possible etiologies for granulomatous conditions excluded beforehand. Following the withdrawal of recombinant interferon-beta and a course of corticosteroids combined with disease-modifying anti-rheumatic drug therapy, the patient's clinical presentation resolved. Excluding ours, only 4 additional cases of sarcoidosis developing after interferon-beta therapy have been reported, with 2 of those cases in the context of underlying multiple sclerosis.
Developing sarcoidosis during treatment of multiple sclerosis with recombinant interferon-beta represents an exceedingly rare and paradoxical adverse event. The occurrence of sarcoidosis with the use of this agent is perhaps due to a dysregulation in the modulatory role played by interferon-beta (and more generally type I interferon) expression in chronic inflammation.
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Details
- Title
- Sarcoidosis triggered by interferon-Beta treatment of multiple sclerosis: a case report and focused literature review
- Creators
- Soumya D Chakravarty - Hospital for Special SurgeryMary E Harris - Cornell UniversityAndrew M Schreiner - New York Hospital QueensMary K Crow - Hospital for Special Surgery
- Publication Details
- Seminars in arthritis and rheumatism, v 42(2), pp 206-212
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Rheumatology; General Internal Medicine
- Web of Science ID
- WOS:000309618300012
- Scopus ID
- 2-s2.0-84866501017
- Other Identifier
- 991021930322504721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Rheumatology