Sarcopenia and mortality among a population‐based sample of community‐dwelling older adults

Justin C Brown; Michael O Harhay; Meera N Harhay

doi:10.1002/jcsm.12073

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Sarcopenia and mortality among a population‐based sample of community‐dwelling older adults

Journal article

Open access

Peer reviewed

Sarcopenia and mortality among a population‐based sample of community‐dwelling older adults

Justin C Brown, Michael O Harhay and Meera N Harhay

Journal of cachexia, sarcopenia and muscle, v 7(3), pp 290-298

Jun 2016

DOI: https://doi.org/10.1002/jcsm.12073

PMID: 27239410

Featured in Collection : UN Sustainable Development Goals @ Drexel

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Abstract

Gait speed

Population based

Cohort study

Skeletal muscle

ESI Highly Cited Paper (Incites)

Obesity

Body Composition

Background Sarcopenia is a risk‐factor for all‐cause mortality among older adults, but it is unknown if sarcopenia predisposes older adults to specific causes of death. Further, it is unknown if the prognostic role of sarcopenia differs between males and females, and obese and non‐obese individuals. Methods A population‐based cohort study among 4425 older adults from the Third National Health and Nutrition Survey (1988–1994). Muscle mass was quantified using bioimpedance analysis, and muscle function was quantified using gait speed. Multivariable‐adjusted Cox regression analysis examined the relationship between sarcopenia and mortality outcomes. Results The mean age of study participants was 70.1 years. The prevalence of sarcopenia was 36.5%. Sarcopenia associated with an increased risk of all‐cause mortality [hazard ratio (HR): 1.29 (95% confidence interval (95% CI): 1.13–1.47); P < 0.001] among males and females. Sarcopenia associated with an increased risk of cardiovascular‐specific mortality among females [HR: 1.61 (95% CI: 1.22–2.12); P = 0.001], but not among males [HR: 1.07 (95% CI: 0.81–1.40; P = .643); Pinteraction = 0.079]. Sarcopenia was not associated with cancer‐specific mortality among males and females [HR: 1.07 (95% CI: 0.78–1.89); P = 0.672]. Sarcopenia associated with an increased risk of mortality from other causes (i.e. non‐cardiovascular and non‐cancer) among males and females [HR: 1.32 (95% CI: 1.07–1.62); P = 0.008]. Obesity, defined using body mass index (Pinteraction = 0.817) or waist circumference (Pinteraction = 0.219) did not modify the relationship between sarcopenia and all‐cause mortality. Conclusions Sarcopenia is a prevalent syndrome that is associated with premature mortality among community‐dwelling older adults. The prognostic value of sarcopenia may vary by cause‐specific mortality and differ between males and females.

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Details

Title: Sarcopenia and mortality among a population‐based sample of community‐dwelling older adults
Creators: Justin C Brown - University of Pennsylvania School of Medicine
Michael O Harhay - University of Pennsylvania School of Medicine
Meera N Harhay - Drexel University College of Medicine
Publication Details: Journal of cachexia, sarcopenia and muscle, v 7(3), pp 290-298
Publisher: Wiley
Number of pages: 9
Grant note: National Cancer Institute (F31‐CA192560; R21‐CA182726) National Heart, Lung, and Blood Institute (F31‐HL127947) National Institute of Diabetes and Digestive and Kidney Diseases (F32‐DK096758)
Resource Type: Journal article
Language: English
Academic Unit: College of Medicine
Web of Science ID: WOS:000379868200006
Scopus ID: 2-s2.0-84978785895
Other Identifier: 991014878447904721