Scanning Electron Microscope Observations of Powder Sticking on Punches during a Limited Number (N < 5) of Compactions of Acetylsalicylic Acid

Henrietta Tsosie; James Thomas; John Strong; Antonios Zavaliangos

doi:10.1007/s11095-017-2186-3

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Scanning Electron Microscope Observations of Powder Sticking on Punches during a Limited Number (N < 5) of Compactions of Acetylsalicylic Acid

Journal article

Peer reviewed

Scanning Electron Microscope Observations of Powder Sticking on Punches during a Limited Number (N < 5) of Compactions of Acetylsalicylic Acid

Henrietta Tsosie, James Thomas, John Strong and Antonios Zavaliangos

Pharmaceutical research, v 34(10), pp 2012-2024

Oct 2017

DOI: https://doi.org/10.1007/s11095-017-2186-3

PMID: 28762201

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Abstract

Adhesiveness

Aspirin - chemistry

Drug Compounding - methods

Equipment Design - instrumentation

Microscopy, Electron, Scanning

Particle Size

Powders

Pressure

Surface Properties

Tablets

Technology, Pharmaceutical

Tensile Strength

To obtain quantitative information and mechanistic insight into the problem of sticking of acetylsalicylic acid tablets on a metallic punch. Low voltage scanning electron microscopy was used to observe punch area coverage and morphology of adhered powder on a flat punch used for a limited number of compactions. Material accumulation in terms of area coverage of the punch per compaction cycle was determined at two pressures over five compactions. The distribution of the adhered material on the punch was non-uniform with more material left on the center of the punch. The sizes of the adhered particles range from 1 to 100 μm, with 50% of the punch surface coverage from particles of an equivalent diameter > 30 μm. Three types of adhered particles were identified after the first compaction: (a) fragments of initial particles with very high aspect ratio, (b) nearly equiaxed fragments with multiple cracks, (c) heavily deformed islands of low profile. Some preliminary ideas that explain these observations are presented and discussed. The ability of SEM to provide quantitative information on sticking from few compactions presents an interesting possibility for a material sparing technique that provides insight on the propensity of sticking.

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14 citations in Scopus

Details

Title: Scanning Electron Microscope Observations of Powder Sticking on Punches during a Limited Number (N < 5) of Compactions of Acetylsalicylic Acid
Creators: Henrietta Tsosie - Drexel University
James Thomas - Drexel University
John Strong - AbbVie
Antonios Zavaliangos - Drexel University
Publication Details: Pharmaceutical research, v 34(10), pp 2012-2024
Publisher: Springer Nature
Resource Type: Journal article
Language: English
Academic Unit: Materials Science and Engineering
Web of Science ID: WOS:000409050300003
Scopus ID: 2-s2.0-85026524742
Other Identifier: 991019168331004721

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Collaboration types: Industry collaboration; Domestic collaboration
Web of Science research areas: Chemistry, Multidisciplinary; Pharmacology & Pharmacy