Journal article
Scopolamine induces recovery of shuttle box avoidance behavior after frontal cortex ablation
Behavioural brain research, v 62(2), pp 135-141
1994
PMID: 7945963
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Abstract
The learning and reversal of shuttle box active avoidance behavior in animals with a bilateral frontal cortex ablation was investigated during and after scopolamine or pilocarpine treatment. Scopolamine facilitated the performance of the avoidance task in normal animals and in those with frontal cortex lesions and also increased the number of intertrial responses, while pilocarpine increased the deleterious effects of the lesions. Furthermore, in the absence of scopolamine, the animals previously treated with the drug showed that its beneficial effects persisted while the number of intertrial responses were no longer increased. The results indicate that the beneficial effects of scopolamine treatment on active avoidance behavior are independent from the effects observed on intertrial activity since only the former are observed after drug withdrawal. Therefore, scopolamine treatment seems to induce a long lasting recovery process in frontal cortex ablated animals.
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Details
- Title
- Scopolamine induces recovery of shuttle box avoidance behavior after frontal cortex ablation
- Creators
- Manuel A Castro-AlamancosJosé Borrell
- Publication Details
- Behavioural brain research, v 62(2), pp 135-141
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:A1994NY04700004
- Scopus ID
- 2-s2.0-0028275479
- Other Identifier
- 991014878445704721
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- Web of Science research areas
- Behavioral Sciences
- Neurosciences