Journal article
Scopolamine modulates apomorphine-induced behavior in rats treated with haloperidol or SCH 23390
European journal of pharmacology, v 148(2), pp 269-272
1988
PMID: 2897925
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Abstract
In acute experiments, scopolamine (1.0 mg/kg) potentiated apomorphine stereotypy and inhibited the antistereotypic effect of both haloperidol (0.5 mg/kg) and SCH 23390 (0.2 mg/kg). Daily administration of either haloperidol (0.5 mg/kg) or SCH 23390 (0.2 mg/kg) for 3 weeks produced enhanced stereotypic responses to apomorphine. Co-administration of scopolamine (1.0 mg/kg) with haloperidol or SCH 23390 significantly reduced the behavioral supersensitivity produced by haloperidol of SCH 23390 alone. It is suggested that both D-1 and D-2 dopamine receptors are linked to a cholinergic mechanism.
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Details
- Title
- Scopolamine modulates apomorphine-induced behavior in rats treated with haloperidol or SCH 23390
- Creators
- Paul Butkerait - Drexel UniversityEitan Friedman - Drexel University
- Publication Details
- European journal of pharmacology, v 148(2), pp 269-272
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:A1988N037100016
- Scopus ID
- 2-s2.0-0023870336
- Other Identifier
- 991019184061904721
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- Web of Science research areas
- Pharmacology & Pharmacy