Journal article
Screening and Prophylaxis for Venous Thromboembolism in Pediatric Surgery: A Systematic Review
Journal of pediatric surgery, v 59(10), 161585
Oct 2024
PMID: 38964986
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The American Pediatric Surgical Association Outcomes and Evidence-Based Practice Committee conducted a systematic review to describe the epidemiology of venous thromboembolism (VTE) in pediatric surgical and trauma patients and develop recommendations for screening and prophylaxis.
The Medline (Ovid), Embase, Cochrane, and Web of Science databases were queried from January 2000 through December 2021. Search terms addressed the following topics: incidence, ultrasound screening, and mechanical and pharmacologic prophylaxis. The Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines were followed. Consensus recommendations were derived based on the best available literature.
One hundred twenty-four studies were included. The incidence of VTE in pediatric surgical populations is 0.29% (Range = 0.1%-0.48%) and directly correlates with surgery type, transfusion, prolonged anesthesia, malignancy, congenital heart disease, inflammatory bowel disease, infection, and female sex. The incidence of VTE in pediatric trauma populations is 0.25% (Range = 0.1%-0.8%) and directly correlates with injury severity, major surgery, central line placement, body mass index, spinal cord injury, and length-of-stay. Routine ultrasound screening for VTE is not recommended. Consider sequential compression devices in at-risk nonmobile, pediatric surgical patients when an appropriate sized device is available. Consider mechanical prophylaxis alone or with pharmacologic prophylaxis in adolescents >15 y and post-pubertal children <15 y with injury severity scores >25. When utilizing pharmacologic prophylaxis, low molecular weight heparin is superior to unfractionated heparin.
While VTE remains an infrequent complication in children, consideration of mechanical and pharmacologic prophylaxis is appropriate in certain populations.
Systematic Review of level 2-4 studies.
Level 3-4.
Metrics
Details
- Title
- Screening and Prophylaxis for Venous Thromboembolism in Pediatric Surgery: A Systematic Review
- Creators
- Lorraine I Kelley-Quon - University of Southern CaliforniaShannon N Acker - University of Colorado DenverShawn St Peter - Sisters of Mercy Health SystemAdam Goldin - Seattle Children's HospitalYasmine Yousef - McGill University Health CentreRobert L Ricca - Prisma HealthSara A Mansfield - Nationwide Children's HospitalJason P Sulkowski - Children's Hospital of Richmond at VCUCarlos T Huerta - University of MiamiDonald J Lucas - Uniformed Services University of the Health SciencesKristy L Rialon - Baylor College of MedicineEmily Christison-Lagay - Yale New Haven HospitalP Benson Ham, 3rd - Division of Pediatric Surgery, John R. Oishei Children's Hospital, University at Buffalo, Buffalo, NY, USARebecca M Rentea - Children's Mercy HospitalAlana L Beres - Drexel UniversityAfif N Kulaylat - Penn State Milton S. Hershey Medical CenterHenry L Chang - Johns Hopkins All Children's HospitalStephanie F Polites - Mayo Clinic in ArizonaDiana L Diesen - The University of Texas Southwestern Medical CenterKatherine W Gonzalez - St. Luke's Children's HospitalDerek Wakeman - University of RochesterRobert Baird - British Columbia Children's Hospital
- Publication Details
- Journal of pediatric surgery, v 59(10), 161585
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Surgery
- Web of Science ID
- WOS:001317987000001
- Scopus ID
- 2-s2.0-85197190968
- Other Identifier
- 991021969585504721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Pediatrics
- Surgery