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Journal article
Screening for new macrophage therapeutics
Theranostics, v 9(25), pp 7714-7729
01 Jan 2019
PMID: 31695796
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Myeloid derived macrophages play a key role in many human diseases, and their therapeutic modulation via pharmacological means is receiving considerable attention. Of particular interest is the fact that these cells are i) dynamic phenotypes well suited to therapeutic manipulation and ii) phagocytic, allowing them to be efficiently targeted with nanoformulations. However, it is important to consider that macrophages represent heterogeneous populations of subtypes with often competing biological behaviors and functions. In order to develop next generation therapeutics, it is therefore essential to screen for biological effects through a combination of in vitro and in vivo assays. Here, we review the state-of-the-art techniques, including both cell based screens and in vivo imaging tools that have been developed for assessment of macrophage phenotype. We conclude with a forward-looking perspective on the growing need for noninvasive macrophage assessment and laboratory assays to be put into clinical practice and the potential broader impact of myeloid-targeted therapeutics.
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Details
- Title
- Screening for new macrophage therapeutics
- Creators
- Christopher B. Rodell - Center for Systems BiologyPeter D. Koch - Harvard UniversityRalph Weissleder - Harvard University
- Publication Details
- Theranostics, v 9(25), pp 7714-7729
- Publisher
- Ivyspring Int Publ
- Number of pages
- 16
- Grant note
- U01CA206997 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) T32CA079443 / US National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000489762700016
- Scopus ID
- 2-s2.0-85074333175
- Other Identifier
- 991019176647004721
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- Web of Science research areas
- Medicine, Research & Experimental