Journal article
Screening of Babesia microti Proteomic Microarrays With Acute and Convalescent Serum of Patients Reveals Novel Targets of Early IgM and IgG Antibodies
The Journal of infectious diseases, v 232(6), pp 1413-1417
15 Dec 2025
PMID: 40673673
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Babesia microti is the cause of a potentially fatal emerging parasitic infection transmitted by ticks. Rapid bedside diagnostic tests are urgently needed. To identify antigens that are targeted by early immune responses, we enrolled 30 patients with confirmed B. microti infection. We used 9 acute, 8 convalescent, and 9 uninfected control sera to screen proteome microarrays of B. microti. We identified 17 antigens that were recognized by IgM and/or IgG antibodies. Twelve of these antigens had not been reported previously. Our approach suggests that there are many antigens that could be used as the basis of rapid bedside diagnostic tests.
Metrics
1 Record Views
Details
- Title
- Screening of Babesia microti Proteomic Microarrays With Acute and Convalescent Serum of Patients Reveals Novel Targets of Early IgM and IgG Antibodies
- Creators
- David Ingram - Penn State Milton S. Hershey Medical CenterJoseph J Campo - Antigen Discovery (United States)Tiffany Bohr - Penn State Milton S. Hershey Medical CenterArlo Z Randall - Antigen Discovery (United States)Xiaowu Liang - Antigen Discovery (United States)Andy A Teng - Antigen Discovery (United States)Jozelyn V Pablo - Antigen Discovery (United States)Chris Hung - Antigen Discovery (United States)Adam D Shandling - Antigen Discovery (United States)Luciano Kapelusznik - Main Line HealthHans H Liu - Main Line HealthDebra Powell - Reading HospitalThong Le - St. Luke's University Health NetworkTonya Crook - Penn State Milton S. Hershey Medical CenterJosé A Stoute (Corresponding Author) - Penn State Milton S. Hershey Medical Center
- Publication Details
- The Journal of infectious diseases, v 232(6), pp 1413-1417
- Publisher
- Oxford University Press
- Grant note
- Pennsylvania Department of Health Pennsylvania State University College of Medicine
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- General Internal Medicine
- Web of Science ID
- WOS:001530108100001
- Scopus ID
- 2-s2.0-105025453185
- Other Identifier
- 991022161843004721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Immunology
- Infectious Diseases
- Microbiology