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Journal article
Seasonality of acquisition of respiratory bacterial pathogens in young children with cystic fibrosis
BMC infectious diseases, v 17(1), pp 411-411
09 Jun 2017
PMID: 28599639
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Seasonal variations are often observed for respiratory tract infections; however, limited information is available regarding seasonal patterns of acquisition of common cystic fibrosis (CF)-related respiratory pathogens. We previously reported differential seasonal acquisition of Pseudomonas aeruginosa in young children with CF and no such variation for methicillin-susceptible Staphylococcus aureus acquisition. The purpose of this study was to describe and compare the seasonal incidence of acquisition of other respiratory bacterial pathogens in young children with CF.
We conducted a retrospective study to describe and compare the seasonal incidence of methicillin-resistant Staphylococcus aureus (MRSA), Stenotrophomonas maltophilia, Achromobacter xylosoxidans, and Haemophilus influenzae acquisition in young CF patients residing in the U.S. using the Cystic Fibrosis Foundation National Patient Registry, 2003-2009. Log-linear overdispersed Poisson regression was used to evaluate seasonal acquisition of each of these pathogens.
A total of 4552 children met inclusion criteria. During follow-up 910 (20%), 1161 (26%), 228 (5%), and 2148 (47%) children acquired MRSA, S. maltophilia, A. xylosoxidans and H. influenzae, respectively. Compared to winter season, MRSA was less frequently acquired in spring (Incidence Rate Ratio [IRR]: 0.79; 95% Confidence Interval [CI]: 0.65, 0.96) and summer (IRR: 0.69; 95% CI: 0.57, 0.84) seasons. Similarly, a lower rate of A. xylosoxidans acquisition was observed in spring (IRR: 0.59; 95% CI: 0.39, 0.89). For H. influenzae, summer (IRR: 0.88; 95% CI: 0.78, 0.99) and autumn (IRR: 0.78; 95% CI: 0.69, 0.88) seasons were associated with lower acquisition rates compared to winter. No seasonal variation was observed for S. maltophilia acquisition.
Acquisition of CF-related respiratory pathogens displays seasonal variation in young children with CF, with the highest rate of acquisition for most pathogens occurring in the winter. Investigation of factors underlying these observed associations may contribute to our understanding of the aetiology of these infections and guide future infection control strategies.
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Details
- Title
- Seasonality of acquisition of respiratory bacterial pathogens in young children with cystic fibrosis
- Creators
- Kevin J Psoter - Johns Hopkins Bayview Medical CenterAnneclaire J De Roos - Drexel UniversityJon Wakefield - University of WashingtonJonathan D Mayer - Departments of Epidemiology, Geography, Global Health, Medicine (Allergy and Infectious Diseases), Family Medicine, and Health Services, University of Washington, Seattle, USAMargaret Rosenfeld - Department of Pediatrics, Seattle Children’s Hospital, Seattle, USA
- Publication Details
- BMC infectious diseases, v 17(1), pp 411-411
- Publisher
- Springer BMC
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Environmental and Occupational Health
- Web of Science ID
- WOS:000403049600002
- Scopus ID
- 2-s2.0-85020457846
- Other Identifier
- 991019169554904721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Infectious Diseases