Journal article
Secnidazole: next-generation antimicrobial agent for bacterial vaginosis treatment
Future microbiology, v 13(5), pp 507-524
01 Apr 2018
PMID: 29327947
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Secnidazole is a next-generation 5-nitroimidazole approved for more than three decades in Europe, Asia, South America and Africa and recently in the USA as a single-dose (2 g) treatment of bacterial vaginosis (BV). Secnidazole is characterized by potent in vitro antimicrobial activity against BV-associated pathogens, as well as prolonged terminal elimination half-life and systemic exposure. These characteristics form the basis of effective and safe treatment of BV with a 2-g single-dose secnidazole regimen, which was recently confirmed in double-blind, placebo-controlled clinical trials conducted in the USA. The option to treat BV with single-dose secnidazole not only cures the primary infection but also may diminish risks of serious sequelae of untreated or undertreated infection.
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Details
- Title
- Secnidazole: next-generation antimicrobial agent for bacterial vaginosis treatment
- Creators
- Paul Nyirjesy - Drexel UniversityJane R. Schwebke - University of Alabama at Birmingham
- Publication Details
- Future microbiology, v 13(5), pp 507-524
- Publisher
- Future Medicine Ltd
- Number of pages
- 18
- Grant note
- Curatek Pharmaceuticals Alfa Wasserman Toltec Pharmaceuticals Symbiomix Therapeutics, LLC StarPharma BD Diagnostics Novadigm Therapeutics Hologic Exeltis USA Viamet Pharmaceuticals Cidara Therapeutics LabCorp of America
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000432200300004
- Scopus ID
- 2-s2.0-85044761917
- Other Identifier
- 991019350670604721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Microbiology