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Journal article
Second trimester amniotic fluid bisphenol A concentration is associated with decreased birth weight in term infants
Reproductive toxicology (Elmsford, N.Y.), v 67, pp 1-9
01 Jan 2017
PMID: 27829162
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Bisphenol A (BPA) is an endocrine disrupting chemical with ubiquitous environmental exposure. Animal studies have demonstrated that in utero BPA exposure leads to increased adult body weight. Our aim was to characterize human fetal BPA exposure by measuring BPA concentration in second trimester amniotic fluid (AF) samples and to study its relationship with birth weight (BW) in full term infants. To achieve these goals, we developed a total BPA assay utilizing derivatization with pentafluorobenzyl followed by analysis with LC-ECAPCI-MS/MS with a limit of detection of 0.08 ng/mL and limit of quantification (LOQ) of 0.25 ng/mL. The mean BW of infants with AF BPA 0.40-2.0 ng/mL was 241.8 g less than infants with AF BPA less than the LOQ after controlling for covariates (p = 0.049). No effect was seen outside this range indicating a non-monotonic effect. Our data suggest that low level BPA exposure in utero decreases BW and needs further study.(C) 2016 Elsevier Inc. All rights reserved.
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Details
- Title
- Second trimester amniotic fluid bisphenol A concentration is associated with decreased birth weight in term infants
- Creators
- Sara E. Pinney - Children's Hospital of PhiladelphiaClementina A. Mesaros - University of PennsylvaniaNathaniel W. Snyder - Drexel UniversityChristine M. Busch - University of PennsylvaniaRui Xiao - University of PennsylvaniaSara Aijaz - Children's Hospital of PhiladelphiaNaila Ijaz - Children's Hospital of PhiladelphiaIan A. Blair - University of PennsylvaniaJeanne M. Manson - Canadensis, PA 18325, United States.
- Publication Details
- Reproductive toxicology (Elmsford, N.Y.), v 67, pp 1-9
- Publisher
- Elsevier
- Number of pages
- 9
- Grant note
- National Institute of Environmental Health Sciences; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) K08DK090302 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) R21HD087866 / EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) K08 DK090302; P30 ES013508; 5R21-ES11675 / National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) K22ES026235 / NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- A.J. Drexel Autism Institute
- Web of Science ID
- WOS:000394195700001
- Scopus ID
- 2-s2.0-84995436833
- Other Identifier
- 991019168013104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Reproductive Biology
- Toxicology