Journal article
Selected Contribution: Effects of ischemia-reperfusion on vascular contractility and α 1 -adrenergic-receptor signaling in the rat tail artery
Journal of applied physiology (1985), v 91(2), pp 1004-1010
01 Aug 2001
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
To determine the effects of ischemia-reperfusion (I/R) on α
1
-adrenergic-receptor (α
1
-AR) functions, α
1
-AR-mediated contraction, inositol phosphate (IP) accumulation, and α
1
-AR-G protein coupling were examined in the tail arteries of anesthetized rats after 60 min of ischemia and 60 min of reperfusion. The contractile response to norepinephrine (NE) was significantly increased after I/R, whereas the contractile response to KCl remained unchanged. This was accompanied by a 69% increase in NE-stimulated IP accumulation. Furthermore, receptor-stimulated coupling of α
1a
-AR to Gα
q/11
proteins was increased, whereas the coupling of α
1b
-AR or α
1d
-AR to their G proteins was not altered by I/R. These changes in vascular α
1
-AR function occurred without concurrent alteration in expression levels of membrane α
1
-AR subtypes or in the associated G proteins. These data demonstrate that I/R increases α
1a
-AR-G
q/11
protein coupling and α
1
-AR-stimulated IP accumulation in the tail artery. The alterations in α
1
-AR signaling are associated with and may underlie the enhanced contractile response of the tail artery to adrenergic stimulation after I/R.
Metrics
Details
- Title
- Selected Contribution: Effects of ischemia-reperfusion on vascular contractility and α 1 -adrenergic-receptor signaling in the rat tail artery
- Creators
- Tammy M. Seasholtz - Department of Pharmacology and Physiology, MCP Hahnemann School of Medicine, Philadelphia, Pennsylvania 19102, USA.Guoping Cai - Department of Pharmacology and Physiology, MCP Hahnemann School of Medicine, Philadelphia, Pennsylvania 19102Hoau-Yan Wang - Department of Pharmacology and Physiology, MCP Hahnemann School of Medicine, Philadelphia, Pennsylvania 19102Eitan Friedman - Department of Pharmacology and Physiology, MCP Hahnemann School of Medicine, Philadelphia, Pennsylvania 19102
- Publication Details
- Journal of applied physiology (1985), v 91(2), pp 1004-1010
- Publisher
- American Physiological Society (APS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000169950900057
- Scopus ID
- 2-s2.0-0034912474
- Other Identifier
- 991019168025304721
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- Web of Science research areas
- Physiology
- Sport Sciences