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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Selective Enhancement of Swine Myocardium with a Novel Ultrasound Enhancing Agent During Transthoracic Echocardiography
Journal of cardiovascular translational research
31 Jan 2022
PMID: 35099715
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Ultrasound enhancing agents are approved to delineate the endocardial border and opacify the left ventricle cavity (LVC). We present a nested phase change agent (NPCA) designed to enable selective myocardial enhancement without enhancing the LVC by employing a dual-activation mechanism dependent on sufficient ultrasound intensity and the microenvironment of the myocardium. Swine received bolus injections of NPCA while echocardiograms were collected and processed to determine background-subtracted acoustic intensities (AI) in the LVC and septal myocardium. At mechanical index (MI) >= 0.8, the NPCA enhanced the myocardium selectively (p < 0.001) while the LVC remained at baseline AI. A 5-mL bolus of NPCA enhanced swine myocardium and enhancement persisted for > 5 min at 1.4 MI, while hemodynamics and EKG remained normal. Our findings demonstrate that the NPCA enhances swine myocardium selectively without enhancing the LVC. The NPCA could have utility for functional and structural echocardiographic studies with clinical ultrasound using standard settings.
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Details
- Title
- Selective Enhancement of Swine Myocardium with a Novel Ultrasound Enhancing Agent During Transthoracic Echocardiography
- Creators
- Michael Cimorelli - Drexel UniversityMichael A. Flynn - Drexel UniversityBrett Angel - Drexel UniversityEmily Reimold - Drexel UniversitySahil S. Banka - Einstein Medical Center PhiladelphiaBenjamin Andrien - Drexel UniversityAaron Fafarman - Drexel UniversityRichard Huneke - Drexel UniversityAndrew Kohut - Raymond and Ruth Perelman School of Medicine at the University of PennsylvaniaSteven Wrenn - Drexel University
- Publication Details
- Journal of cardiovascular translational research
- Publisher
- Springer Nature
- Number of pages
- 8
- Grant note
- P200 A150240 / Department of Education; US Department of Education Coulter-Drexel Translational Research Partnership Program
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology; College of Medicine; Chemical and Biological Engineering; Chemistry
- Web of Science ID
- WOS:000750454600001
- Scopus ID
- 2-s2.0-85123945722
- Other Identifier
- 991019169009404721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Cardiac & Cardiovascular Systems
- Medicine, Research & Experimental