Journal article
Selective Export of MHC Class I Molecules from the ER after Their Dissociation from TAP
Immunity (Cambridge, Mass.), v 13(6), pp 841-851
2000
PMID: 11163199
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
It has been assumed that upon dissociation from TAP, MHC class I molecules exit the ER by nonselective bulk flow. We now show that exit must occur by association with cargo receptors. Inconsistent with exit by bulk flow, loading of MHC class I molecules with high-affinity peptides triggers dissociation from TAP but has no effect on rates of ER-to-Golgi transport. Moreover, peptide-loaded MHC class I molecules accumulate at ER exit sites from which TAP molecules are excluded. Consistent with receptor-mediated exit, ER-to-Golgi transport of MHC class I molecules is independent of their cytoplasmic tails, which themselves lack ER export motifs. In addition, we show that MHC class I molecules associate with the putative cargo receptor BAP31.
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Details
- Title
- Selective Export of MHC Class I Molecules from the ER after Their Dissociation from TAP
- Creators
- Elias T. Spiliotis - Johns Hopkins UniversityManuel Osorio - University of California, Santa CruzMartha C. Zúñiga - University of California, Santa CruzMichael Edidin - Johns Hopkins University
- Publication Details
- Immunity (Cambridge, Mass.), v 13(6), pp 841-851
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology
- Web of Science ID
- WOS:000166142300009
- Scopus ID
- 2-s2.0-0034517368
- Other Identifier
- 991020112148304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Immunology