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Selective Export of MHC Class I Molecules from the ER after Their Dissociation from TAP
Journal article   Open access   Peer reviewed

Selective Export of MHC Class I Molecules from the ER after Their Dissociation from TAP

Elias T. Spiliotis, Manuel Osorio, Martha C. Zúñiga and Michael Edidin
Immunity (Cambridge, Mass.), v 13(6), pp 841-851
2000
PMID: 11163199
url
http://www.cell.com/article/S1074761300000819/pdfView
Published, Version of Record (VoR) Open
url
https://doi.org/10.1016/S1074-7613(00)00081-9View
Published, Version of Record (VoR) Open

Abstract

It has been assumed that upon dissociation from TAP, MHC class I molecules exit the ER by nonselective bulk flow. We now show that exit must occur by association with cargo receptors. Inconsistent with exit by bulk flow, loading of MHC class I molecules with high-affinity peptides triggers dissociation from TAP but has no effect on rates of ER-to-Golgi transport. Moreover, peptide-loaded MHC class I molecules accumulate at ER exit sites from which TAP molecules are excluded. Consistent with receptor-mediated exit, ER-to-Golgi transport of MHC class I molecules is independent of their cytoplasmic tails, which themselves lack ER export motifs. In addition, we show that MHC class I molecules associate with the putative cargo receptor BAP31.

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Collaboration types
Domestic collaboration
Web of Science research areas
Immunology
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