Journal article
Selective Reduction of Serotonin Storage and ATP Release in Chronic Renal Failure Patient Platelets
American journal of hematology, v 35(3), pp 171-178
Nov 1990
PMID: 2220759
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Hemorrhagic complications, as monitored by skin bleeding times, occur in a significant number of chronic renal failure (CRF) patients. The etiology of hemostatic defects in these patients is complex and ill defined. Our studies demonstrate, for the first time, that activated platelets, derived from CRF patients, release significantly (P < 0.001) less ATP than controls while the percent of releasable serotonin (5HT), assumed to be co‐stored with ATP, is unaltered. Analysis of the CRF‐derived platelets reflects a selective acquired storage pool defect with significantly (P < 0.001) reduced 5HT levels while their dense granule contents of ATP and ADP are normal. The comparison of ATP release from platelets derived from CRF patients whose bleeding times were less than 9 min to those with bleeding times of 9 min or greater was significantly different (P < 0.02). This report demonstrates for the first time that there is a statistically significant correlation of ATP release and 5HT content to bleeding times (P < 0.001). The perturbation of platelet 5HT uptake, 5HT dense granule content, and ATP release appears to result from newly described altered plasma factors, detected by our in vitro mixing studies. It is proposed that the reduced level of releasable platelet 5HT and ATP contributes to bleeding disorders commonly encountered in CRF patients.
Metrics
Details
- Title
- Selective Reduction of Serotonin Storage and ATP Release in Chronic Renal Failure Patient Platelets
- Creators
- Gerald SoslauJanet ParkerIsadore BrodskyBhaben PutatundaAllan B Schwartz
- Publication Details
- American journal of hematology, v 35(3), pp 171-178
- Publisher
- Wiley Subscription Services, Inc., A Wiley Company; New York
- Number of pages
- 8
- Grant note
- BRSG (2S07 RR 50413)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Nephrology (and Hypertension); [Retired Faculty]
- Web of Science ID
- WOS:A1990ED66000005
- Scopus ID
- 2-s2.0-0025187286
- Other Identifier
- 991014878293204721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Hematology