Journal article
Selective attenuation of psychostimulant-induced behavioral responses in mice lacking A 2A adenosine receptors
Neuroscience, v 97(1), pp 195-204
2000
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
A
2A adenosine receptors are highly expressed in the striatum where they modulate dopaminergic activity. The role of A
2A receptors in psychostimulant action is less well understood because of the lack of A
2A-selective compounds with access to the central nervous system. To investigate the A
2A adenosinergic regulation of psychostimulant responses, we examined the consequences of genetic deletion of A
2A receptors on psychostimulant-induced behavioral responses. The extent of dopaminergic innervation and expression of dopamine receptors in the striatum were indistinguishable between A
2A receptor knockout and wild-type mice. However, locomotor responses to amphetamine and cocaine were attenuated in A
2A knockout mice. In contrast, D
1-like receptor agonists SKF81297 and SKF38393 produced identical locomotor stimulation and grooming, respectively, in wild-type and A
2A knockout mice. Similarly, the D
2-like agonist quinpirole produced motor-depression and stereotypy that were indistinguishable between A
2A knockout and wild-type mice. Furthermore, attenuated amphetamine- (but not SKF81297-) induced locomotion was observed in pure 129-Steel as well as hybrid 129-Steel×C57BL/6 mice, confirming A
2A receptor deficiency (and not genetic background) as the cause of the blunted psychostimulant responses in A
2A knockout mice.
These results demonstrate that A
2A receptor deficiency selectively attenuates psychostimulant-induced behavioral responses and support an important role for the A
2A receptor in modulating psychostimulant effects.
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Details
- Title
- Selective attenuation of psychostimulant-induced behavioral responses in mice lacking A 2A adenosine receptors
- Creators
- J.-F Chen - Harvard UniversityM Beilstein - Harvard UniversityY.-H Xu - Harvard UniversityT.J Turner - Tufts UniversityR Moratalla - Harvard UniversityD.G Standaert - Harvard UniversityV.J Aloyo - Hahnemann University HospitalJ.S Fink - Harvard UniversityM.A Schwarzschild - Harvard University
- Publication Details
- Neuroscience, v 97(1), pp 195-204
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000086751600019
- Scopus ID
- 2-s2.0-0034037134
- Other Identifier
- 991019167697704721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences