Journal article
Selective dopaminergic mechanism of dopamine and SKF38393 stimulation of inositol phosphate formation in rat brain
European journal of pharmacology. Molecular pharmacology section, v 226(4), pp 297-302
1992
PMID: 1327844
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
We have previously reported that dopamine and the D
1 receptor-selective agonist, SKF38393, stimulate the formation of inositol phosphates in rat brain slices (Undie and Friedman, 1990, J. Pharmacol. Exp. Ther. 253, 987). The present experiments were conducted to determine if actions at α-adrenoceptors or at serotonergic sites may contribute to, or interact with, the observed stimulation of phosphoinositide hydrolysis by dopamine receptor agonists. Rat striatal slices prelabeled with [
3H]inositol were treated with up to 500 μM dopamine, norepinephrine, serotonin (5-HT), or the dopamine D
1 receptor agonist, SKF38393, and accumulated inositol phosphates determined. The action of norepinephrine was dose-dependently blocked by the selective
α
1-adrenoceptor antagonist, prazosin, but not by SCH23390. The actions of dopamine and SKF38393 were dose-dependently blocked by the dopamine D
1 receptor antagonist, SCH23390, but not by prazosin. The effects of 5-HT were blocked by the nonselective 5-HT antagonist, methiotepin, the selective 5-HT
2 antagonist, ketanserin, the mixed 5-HT
2/5-HT
1C antagonist, mianserin, and, with much less potency, by the selective 5-HT
1C antagonist, mesulergine. On the contrary, the serotonin receptor antagonists did not block the response to SKF38393, and there was no dose-dependent blockade of the 5-HT response by SCH23390. These observations indicate that the actions of dopamine and SKF38393 in stimulating inositol phosphate formation are selectively mediated through a D
1-like dopamine receptor.
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Details
- Title
- Selective dopaminergic mechanism of dopamine and SKF38393 stimulation of inositol phosphate formation in rat brain
- Creators
- Ashiwel S. Undie - Drexel UniversityEitan Friedman - Drexel University
- Publication Details
- European journal of pharmacology. Molecular pharmacology section, v 226(4), pp 297-302
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:A1992JG59200003
- Scopus ID
- 2-s2.0-0026721896
- Other Identifier
- 991019184202104721
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- Web of Science research areas
- Pharmacology & Pharmacy