Selective modulation of excitatory and inhibitory microcircuits by dopamine

Wen-Jun Gao; Patricia S Goldman-Rakic

doi:10.1073/pnas.262796399

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Selective modulation of excitatory and inhibitory microcircuits by dopamine

Journal article

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Selective modulation of excitatory and inhibitory microcircuits by dopamine

Wen-Jun Gao and Patricia S Goldman-Rakic

Proceedings of the National Academy of Sciences - PNAS, Vol.100(5), pp.2836-2841

04 Mar 2003

DOI: https://doi.org/10.1073/pnas.262796399

PMCID: PMC151427

PMID: 12591942

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Abstract

Neurons - pathology

Synaptic Transmission - physiology

Synapses - physiology

Dopamine - pharmacology

Electrophysiology

Neurons - cytology

Ferrets

Axons

Animals

Synapses - metabolism

Time Factors

Pyramidal Cells - physiology

Neurons - physiology

Synaptic Transmission - drug effects

Neurons - metabolism

Pyramidal Cells - drug effects

Neural Inhibition - drug effects

Prefrontal Cortex - physiology

Dopamine - metabolism

Dopamine plays an important role in the working memory functions of the prefrontal cortex, functions that are impacted in age-related memory decline, drug abuse, and a wide variety of disorders, including schizophrenia and Parkinson's disease. We have previously reported that dopamine depresses excitatory transmission between pyramidal neurons in the prefrontal cortex. Here, using paired recordings, we have investigated dopaminergic modulation of excitatory transmission from pyramidal neurons to fast-spiking (FS) interneurons. In contrast to its effect on recurrent excitation, dopamine was without effect on excitatory transmission to FS interneurons. However, dopamine has directly enhanced the excitability of the FS interneurons to the extent that even a single excitatory postsynaptic potential could initiate spiking with great temporal precision in some of them. These results indicate that dopamine's effects on excitatory transmission are target-specific and that the axon terminals of pyramidal neurons can be selectively regulated at the level of individual synapses. Thus, dopamine's net inhibitory effect on cortical function is remarkably constrained by the nature of the microcircuit elements on which it acts.

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Title: Selective modulation of excitatory and inhibitory microcircuits by dopamine
Creators: Wen-Jun Gao - Department of Neurobiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA
Patricia S Goldman-Rakic
Publication Details: Proceedings of the National Academy of Sciences - PNAS, Vol.100(5), pp.2836-2841
Publisher: PNAS; United States
Grant note: R01 MH085666 / NIMH NIH HHS R37 MH038546 / NIMH NIH HHS MH38546 / NIMH NIH HHS R01 MH038546 / NIMH NIH HHS MH44866 / NIMH NIH HHS
Resource Type: Journal article
Language: English
Academic Unit: Neurobiology and Anatomy
Identifiers: 991014878259704721

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Web of Science research areas: Neurosciences

Selective modulation of excitatory and inhibitory microcircuits by dopamine

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