Journal article
Selective protection from the inhibition by EEDQ of D 1 and D 2 dopamine agonist-induced rotational behavior in mice
Pharmacology, biochemistry and behavior, v 30(2), pp 457-462
1988
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Abstract
Mice with unilateral lesions of dopamine nigrostriatal neurons produced by injecting 6-hydroxydopamine into the striatum exhibited contralateral rotational behavior to the non-selective dopamine agonist apomorphine, the D
1 dopamine agonist SKF 38393, and the D
2 agonist quinpirole. The non-specific dopamine antagonist EEDQ blocked the circling responses to the three agonists. Pretreatment with specific, reversible dopamine antagonists before the EEDQ injection selectively prevented this blockade. Thus, if mice were pretreated with the D
1 receptor antagonist SCH 23390 before EEDQ and the animals challenged with the D
1 and D
2 agonists 24 hours later, the rotational response to quinpirole was still inhibited, but the response to SKF 38393 was now evident. Similarly, in mice pretreated with the D
2 receptor antagonist sulpiride before EEDQ and again challenged with the D
1 and D
2 agonists 24 hours later, the rotational response to SKF 38393 was still inhibited but the response to quinpirole was no longer inhibited. These results indicate that in vivo blockade of either D
1 or D
2 subpopulations of dopamine receptors may be achieved by selective protection with a reversible dopamine antagonist given prior to the administration of an irreversibly acting dopamine antagonist such as EEDQ.
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Details
- Title
- Selective protection from the inhibition by EEDQ of D 1 and D 2 dopamine agonist-induced rotational behavior in mice
- Creators
- David B. Goodale - Division of Neuropsychopharmacology, Departments of Pharmacology and Anesthesiology Medical College of Pennsylvania at Eastern Pennsylvania Psychiatric Institute 3200 Henry Avenue, Philadelphia, PA 19129, USAAthole G. McNeil JacobiDonald M. Seyfried - Division of Neuropsychopharmacology, Departments of Pharmacology and Anesthesiology Medical College of Pennsylvania at Eastern Pennsylvania Psychiatric Institute 3200 Henry Avenue, Philadelphia, PA 19129, USABenjamin Weiss - Division of Neuropsychopharmacology, Departments of Pharmacology and Anesthesiology Medical College of Pennsylvania at Eastern Pennsylvania Psychiatric Institute 3200 Henry Avenue, Philadelphia, PA 19129, USA
- Publication Details
- Pharmacology, biochemistry and behavior, v 30(2), pp 457-462
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:A1988P182400027
- Scopus ID
- 2-s2.0-0024159551
- Other Identifier
- 991019184068604721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Behavioral Sciences
- Neurosciences
- Pharmacology & Pharmacy