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Journal article
Selective suppression of excitatory synapses on GABAergic interneurons by norepinephrine in juvenile rat prefrontal cortical microcircuitry
Neuroscience, v 246, pp 312-328
14 May 2013
PMID: 23684615
Abstract
The noradrenergic system of the brain is thought to facilitate neuronal processes that promote behavioral activation, alertness, and attention. It is known that norepinephrine (NE) can be significantly elevated in the prefrontal cortex under normal conditions such as arousal and attention, and following administration of psychostimulants and various other drugs prescribed for psychiatric disorders. However, how NE modulates neuronal activity and synapses in the local prefrontal circuitry remains elusive. In this study, we characterized the actions of NE on individual monosynaptic connections among layer V pyramidal neurons (P) and fast-spiking (FS) GABAergic interneurons in the juvenile (postnatal days 20–23) rat prefrontal local circuitry. We found that NE selectively depresses excitatory synaptic transmission in P-FS connections but has no detectable effect on the excitatory synapses in P-P connections and the inhibitory synapses in FS-P connections. NE apparently exerts distinctly different modulatory actions on identified synapses that target GABAergic interneurons but has no effect on those in the pyramidal neurons in this specific developmental period. These results indicate that, depending on the postsynaptic targets, the effects of NE in prefrontal cortex are synapse-specific, at least in the juvenile animals.
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Details
- Title
- Selective suppression of excitatory synapses on GABAergic interneurons by norepinephrine in juvenile rat prefrontal cortical microcircuitry
- Creators
- Huai-Xing Wang - Drexel UniversityBarry D. Waterhouse - Drexel UniversityWen-Jun Gao - Drexel University
- Publication Details
- Neuroscience, v 246, pp 312-328
- Publisher
- Elsevier
- Grant note
- P50 MH068789 || MH / National Institute of Mental Health : NIMH R01 MH085666 || MH / National Institute of Mental Health : NIMH R21 MH079117 || MH / National Institute of Mental Health : NIMH
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy; [Retired Faculty]
- Web of Science ID
- WOS:000321168000028
- Scopus ID
- 2-s2.0-84878909611
- Other Identifier
- 991019168200504721
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- Web of Science research areas
- Neurosciences