Journal article
Self-Actuated, Thermo-Responsive Hydrogel Valves for Lab on a Chip
Biomedical microdevices, v 7(4), pp 313-322
Dec 2005
PMID: 16404509
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
An easy to fabricate, thermally-actuated, self-regulated hydrogel valve for flow control in pneumatically driven, microfluidic systems is described. This microvalve takes advantage of the properties of the hydrogel, poly(N-isopropylacrylamide), as well as the aqueous fluid itself to realize flow control. The valve was designed for use in a diagnostic system fabricated with polycarbonate and aimed at the detection of pathogens in oral fluids at the location of the sample collection. The paper describes the construction and characterization of the hydrogel valves and their application for flow control, sample and reagent metering, sample distribution into multiple analysis paths, and the sealing of a polymerase chain reaction (PCR) reactor to suppress bubble formation. The hydrogel-based flow control is electronically addressable, does not require any moving parts, introduces minimal dead volume, is leakage and contaminant free, and is biocompatible.
Metrics
Details
- Title
- Self-Actuated, Thermo-Responsive Hydrogel Valves for Lab on a Chip
- Creators
- Jing Wang - University of PennsylvaniaZongyuan Chen - University of PennsylvaniaMichael Mauk - University of PennsylvaniaKuang-Sheng Hong - University of PennsylvaniaMengyan Li - Drexel UniversityShu Yang - University of PennsylvaniaHaim Bau - University of Pennsylvania
- Publication Details
- Biomedical microdevices, v 7(4), pp 313-322
- Publisher
- Kluwer Academic Publishers; Boston
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Engineering Technology
- Web of Science ID
- WOS:000234512600006
- Scopus ID
- 2-s2.0-33645222934
- Other Identifier
- 991014877668804721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Engineering, Biomedical
- Nanoscience & Nanotechnology