Journal article
Self-Assembly of an Antiangiogenic Nanofibrous Peptide Hydrogel
ACS applied bio materials, Vol.1(3), pp.865-870
17 Sep 2018
PMID: 34996179
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Pathological neovascularization may cause or worsen intraocular posterior segment diseases such as diabetic retinopathy. Prevention of aberrant vascularization is thus an important clinical target. Therapeutic antiangiogenic agents are generally used in diffusible monomeric formulation (e.g., injection of anti-VEGF monoclonal antibodies into the vitreous humor). Here, we report the attachment of a therapeutic antiangiogenic motif to a fibrillizing peptide backbone that undergoes nanofibrous self-assembly into an injectable hydrogel. The peptide can persist for extended periods in a target site, prolonging the therapeutic time frame. The injectability of the hydrogel was investigated through rheometric characterization. Biophysical characterization was complemented by in vitro assays to test the antiangiogenic capability of the scaffold. We also tested persistence and biocompatibility of the hydrogel through in vivo implantation. This injectable hydrogel therapy may unlock potential clinical routes for treating neovascular diseases.
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Details
- Title
- Self-Assembly of an Antiangiogenic Nanofibrous Peptide Hydrogel
- Creators
- Peter K. Nguyen - New Jersey Institute of TechnologyBiplab Sarkar - New Jersey Institute of TechnologyZain Siddiqui - New Jersey Institute of TechnologyMichael McGowan - New Jersey Institute of TechnologyPatricia Iglesias-Montoro - New Jersey Institute of TechnologySruti Rachapudi - New Jersey Institute of TechnologySoojin Kim - New Jersey Institute of TechnologyWilliam Gao - New Jersey Institute of TechnologyEun Jung Lee - New Jersey Institute of TechnologyVivek A. Kumar - Rutgers, The State University of New Jersey
- Publication Details
- ACS applied bio materials, Vol.1(3), pp.865-870
- Publisher
- Amer Chemical Soc
- Number of pages
- 6
- Grant note
- NJIT startup funds
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Identifiers
- 991021956861304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Materials Science, Biomaterials
- Nanoscience & Nanotechnology