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Self-appraisal in behavioural variant frontotemporal degeneration
Journal article   Open access   Peer reviewed

Self-appraisal in behavioural variant frontotemporal degeneration

Lauren Massimo, David J Libon, Keerthi Chandrasekaran, Michael Dreyfuss, Corey T McMillan, Katya Rascovsky, Ashley Boller and Murray Grossman
Journal of neurology, neurosurgery and psychiatry, v 84(2), pp 148-153
01 Feb 2013
DOI: https://doi.org/10.1136/jnnp-2012-303153
PMID: 22952324
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://europepmc.org/articles/pmc3556171View
Accepted (AM)Open Access (License Unspecified),  Open

Abstract

Objective Previous work investigating deficits in self-appraisal in behavioural-variant frontotemporal degeneration (bvFTD) has focused on a single domain: social/behavioural processes. We examined whether a domain-specific versus multi-domain model best explains degraded self-appraisal in bvFTD. Methods 49 patients with bvFTD and 73 patients with Alzheimer's disease (AD) were administered quantitative assessments of episodic memory, naming and grammatical comprehension. Self-appraisal of cognitive test performance was assessed by asking patients to rate their performance immediately after completing each neuropsychological test. A discrepancy score was created to reflect the difference between patient performance on neuropsychological tests and self-appraisal of their test performance. Self-appraisal for each neuropsychological measure was related to grey matter (GM) density in each group using voxel-based morphometry. Results bvFTD patients were poor at evaluating their own performance on all cognitive tests, with no significant correlations between self-appraisal and actual performance. By contrast, poor self-appraisal in AD was restricted to episodic memory performance. Poor self-appraisal on each task in bvFTD and AD was related to reduced GM density in several ventral and rostral medial prefrontal regions. Crucially, poor self-appraisal for all domains in bvFTD was related to a specific area of reduced GM density in the subgenual cingulate (BA 25). Conclusion Poor self-appraisal in bvFTD affects multiple domains, and this multi-domain impairment pattern is associated with frontal disease in the subgenual cingulate.

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29 citations in Web of Science
31 citations in Scopus

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Collaboration types
Domestic collaboration
Web of Science research areas
Clinical Neurology
Psychiatry
Surgery
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