Journal article
Self-appraisal in behavioural variant frontotemporal degeneration
Journal of neurology, neurosurgery and psychiatry, v 84(2), pp 148-153
01 Feb 2013
PMID: 22952324
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective Previous work investigating deficits in self-appraisal in behavioural-variant frontotemporal degeneration (bvFTD) has focused on a single domain: social/behavioural processes. We examined whether a domain-specific versus multi-domain model best explains degraded self-appraisal in bvFTD. Methods 49 patients with bvFTD and 73 patients with Alzheimer's disease (AD) were administered quantitative assessments of episodic memory, naming and grammatical comprehension. Self-appraisal of cognitive test performance was assessed by asking patients to rate their performance immediately after completing each neuropsychological test. A discrepancy score was created to reflect the difference between patient performance on neuropsychological tests and self-appraisal of their test performance. Self-appraisal for each neuropsychological measure was related to grey matter (GM) density in each group using voxel-based morphometry. Results bvFTD patients were poor at evaluating their own performance on all cognitive tests, with no significant correlations between self-appraisal and actual performance. By contrast, poor self-appraisal in AD was restricted to episodic memory performance. Poor self-appraisal on each task in bvFTD and AD was related to reduced GM density in several ventral and rostral medial prefrontal regions. Crucially, poor self-appraisal for all domains in bvFTD was related to a specific area of reduced GM density in the subgenual cingulate (BA 25). Conclusion Poor self-appraisal in bvFTD affects multiple domains, and this multi-domain impairment pattern is associated with frontal disease in the subgenual cingulate.
Metrics
Details
- Title
- Self-appraisal in behavioural variant frontotemporal degeneration
- Creators
- Lauren Massimo - University of PennsylvaniaDavid J Libon - Drexel UniversityKeerthi Chandrasekaran - University of PennsylvaniaMichael Dreyfuss - University of PennsylvaniaCorey T McMillan - University of PennsylvaniaKatya Rascovsky - University of PennsylvaniaAshley Boller - University of PennsylvaniaMurray Grossman - University of Pennsylvania
- Publication Details
- Journal of neurology, neurosurgery and psychiatry, v 84(2), pp 148-153
- Publisher
- British Medical Journal (BMJ)
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000313554700008
- Scopus ID
- 2-s2.0-84872683981
- Other Identifier
- 991021901011904721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
Source: SDGs in the Output
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Clinical Neurology
- Psychiatry
- Surgery