Journal article
Self-assembled Nucleic Acid Nanostructures for Cancer Theranostic Medicines
Current topics in medicinal chemistry, v 17(16), pp 1815-1828
01 Jan 2017
PMID: 27875979
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Theranostic medicine has become more promising in cancer treatment, where the cancer diagnosis and chemotherapy are combined for early diagnosis and precise treatment with improved efficacy and reduced side effects. Nanotechnology has played a critical role in developing various nanomaterials with engendered smart functions and targeted delivery. The rapid development of structural DNA nanotechnology has enabled the design and fabrication of complex nanostructures with prescribed 1D, 2D and 3D patterns in vitro and in vivo. Self-assembled DNA nanostructures can serve as drug delivery platforms that are integrated with various functions ranging from molecular recognition and computations, dynamically structural switch to carrying molecular payloads and selectively release. In this review, we summarize recent exciting progress of using DNA nanostructures to engineer novel smart drug-delivery systems potential for treating cancer.
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Details
- Title
- Self-assembled Nucleic Acid Nanostructures for Cancer Theranostic Medicines
- Creators
- Jinglin Fu - Rutgers, The State University of New JerseyGabriele Stankeviciute - Rutgers State Univ, Dept Chem, Camden, NJ USASung Won Oh - Rutgers, The State University of New JerseyJohn Collins - Rutgers State Univ, Dept Chem, Camden, NJ USAYinghui Zhong - Drexel UniversityTing Zhang - Rutgers State Univ, Dept Chem, Camden, NJ USA
- Publication Details
- Current topics in medicinal chemistry, v 17(16), pp 1815-1828
- Publisher
- Bentham Science Publ Ltd
- Number of pages
- 14
- Grant note
- Rutgers University-Camden Cottrell College Science Award W911NF-14-1-0434 / Army Research Office Young Investigator award
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000402480600003
- Scopus ID
- 2-s2.0-85020436921
- Other Identifier
- 991019167327604721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Chemistry, Medicinal