Journal article
Self-reported experiences of discrimination and inflammation among men and women: The multi-ethnic study of atherosclerosis
Health psychology, v 35(4), pp 343-350
Apr 2016
PMID: 27018725
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
To examine associations of lifetime and everyday discrimination with inflammation independent of sociodemographic characteristics.
Cross-sectional associations of self-reported experiences of everyday discrimination and lifetime discrimination with interleukin-6 (IL-6) and C-reactive protein (CRP) were examined by gender in a multiethnic sample of 3,099 men and 3,468 women aged 45-84 years. Everyday discrimination, lifetime discrimination due to any attribution, and lifetime discrimination attributed to race/ethnicity were based on self-report, and IL-6 and CRP were assayed from blood samples.
Among women, higher levels of all 3 discrimination measures were significantly associated with higher IL-6 in models adjusted for sociodemographic characteristics, recent infection, anti-inflammatory medication use, and hormone replacement therapy use. All associations were attenuated with adjustment for body mass index (BMI). For men, everyday discrimination was inversely associated with IL-6 in all adjusted models. Lifetime discrimination was not related to IL-6 among men. Discrimination was unassociated with CRP in all models for both men and women.
The association between discrimination and inflammation varied by gender and marker of inflammation. These findings highlight the complex relationship between discrimination and cardiovascular disease (CVD) risk and point to areas in need of further research. (PsycINFO Database Record
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Details
- Title
- Self-reported experiences of discrimination and inflammation among men and women: The multi-ethnic study of atherosclerosis
- Creators
- Kiarri N Kershaw - Department of Preventive Medicine, Northwestern University, Feinberg School of Medicine;Tené T Lewis - Emory UniversityAna V Diez Roux - Drexel UniversityNancy S Jenny - University of VermontKiang Liu - Department of Preventive Medicine, Northwestern University, Feinberg School of Medicine;Frank J Penedo - Department of Medical Social Sciences , Northwestern University Feinberg School of MedicineMercedes R Carnethon - Department of Preventive Medicine, Northwestern University, Feinberg School of Medicine;
- Publication Details
- Health psychology, v 35(4), pp 343-350
- Grant note
- N01HC95159 / NHLBI NIH HHS N01HC95169 / NHLBI NIH HHS UL1-RR-024156 / NCRR NIH HHS N01-HC-95159 / NHLBI NIH HHS N01 HC095159 / NHLBI NIH HHS UL1 RR025005 / NCRR NIH HHS UL1-RR-025005 / NCRR NIH HHS UL1 RR024156 / NCRR NIH HHS P60 MD002249 / NIMHD NIH HHS N01-HC-95169 / NHLBI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative
- Web of Science ID
- WOS:000373477600005
- Scopus ID
- 2-s2.0-84963956098
- Other Identifier
- 991019167919904721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Psychology
- Psychology, Clinical