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Self-reported major mobility disability and mortality among cancer survivors
Journal article   Open access   Peer reviewed

Self-reported major mobility disability and mortality among cancer survivors

Justin C. Brown, Michael O. Harhay and Meera N. Harhay
Journal of geriatric oncology, v 9(5), pp 459-463
Sep 2018
DOI: https://doi.org/10.1016/j.jgo.2018.03.004
PMID: 29550343
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.1016/j.jgo.2018.03.004View
Accepted (AM)Open Access (License Unspecified),  Open

Abstract

Ambulation Patient reported outcome Physical activity Physical function Survival
To quantify the prevalence of self-reported major mobility disability (SR-MMD) and its association with mortality in a nationally-representative sample of cancer survivors. This study included patients with a history of cancer who participated in the National Health and Nutrition Examination Survey 19992010. SR-MMD was defined as self-reported difficulty or inability to walk a quarter of a mile. Vital status through December 15, 2011 was ascertained from the United States National Center for Health Statistics. Multivariable-adjusted Cox regression models were used to quantify the hazard ratio (HR) and 95% confidence interval (CI) between SR-MMD and mortality. The study included 1458 cancer survivors who averaged 67.1 years of age. At baseline, 201 (13.7%) participants had SR-MMD. During a median follow-up of 4.7 years, 434 (29.8%) participants died. SR-MMD was independently associated with a higher risk of all-cause mortality [HR: 2.15 (95% CI: 1.56–2.97); P < 0.001] and cancer-specific mortality [HR: 2.49 (95% CI: 1.53–4.07); P < 0.001]. The association between SR-MMD and all-cause mortality was not modified by age, sex, time since cancer diagnosis, body mass index, or comorbid health conditions. SR-MMD is an easily ascertainable metric of physical function that is associated with a higher risk of mortality among cancer survivors. Integrating measures of physical function may help to guide clinical decision-making and improve long-term prognostication in this population. Interventions that prevent the development of SR-MDD, such as physical activity, should be evaluated in this population.

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UN Sustainable Development Goals (SDGs)

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#3 Good Health and Well-Being

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Collaboration types
Domestic collaboration
Web of Science research areas
Geriatrics & Gerontology
Oncology
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