Journal article
Self-reported sleep disturbance in Crohn's disease is not confirmed by objective sleep measures
Scientific reports, v 10(1), pp 1980-1980
06 Feb 2020
PMID: 32029832
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Sleep disturbance and fatigue are commonly reported among patients with Crohn's disease (CD). In this prospective study, we aimed to define sleep quality in CD patients at various disease activity states and compare to healthy controls using objective and subjective measures. A prospective observational cohort study of CD patients seen at a tertiary academic inflammatory bowel diseases (IBD) clinic was compared to healthy volunteers. CD activity was assessed using the Harvey-Bradshaw Index (HBI). Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI) and Epworth Sleepiness Scale (ESS) and objectively over 1-week using actigraphy (motion-based) and morning urinary melatonin metabolite. 121 subjects (CD patients N=61; controls N=60) completed the study. 34 had active CD (HBI>4). Sleep disturbance was more frequently reported by CD subjects than controls (PSQI: 57% vs. 35%, p=0.02) and in patients with active CD versus in remission state (PSQI 75.8% vs. 33.3%, p<0.01; ESS: 45.5% vs. 19%, p=0.03). Sleep parameters as measured by actigraphy and urine melatonin metabolite did not vary by group. Crohn's patients report significantly more disturbed sleep than controls. However, poor sleep was not confirmed by objective measures of sleep quality. Excessive daytime sleepiness in CD patients may be driven by factors beyond objectively measured poor sleep.
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Details
- Title
- Self-reported sleep disturbance in Crohn's disease is not confirmed by objective sleep measures
- Creators
- Heba N. Iskandar - Emory UniversityEmily E. Linan - Washington University in St. LouisAmi Patel - Duke UniversityRenee Moore - Emory UniversityYi Lasanajak - Emory UniversityC. Prakash Gyawali - Washington University in St. LouisGregory S. Sayuk - Washington University in St. LouisMatthew A. Ciorba - Washington University in St. Louis
- Publication Details
- Scientific reports, v 10(1), pp 1980-1980
- Publisher
- NATURE PORTFOLIO
- Number of pages
- 9
- Grant note
- Washington University School of Medicine Mentors in Medicine Program ACG-CR-043-2013; UL1TR002378; 1K08DK089016; K23 DK084113 / ACG Clinical Research Award P30 DK052574 / NIDDK; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) 5T32DK007130-36; UL1TR000448 / ACG clinical research award pilot grant AMI
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:000559759000011
- Scopus ID
- 2-s2.0-85079059618
- Other Identifier
- 991021448033804721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Gastroenterology & Hepatology