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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Semi-degradable scaffold for articular cartilage replacement
Tissue engineering. Part A, v 14(1), pp 207-213
01 Jan 2008
PMID: 18333818
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Existing technologies have not met the challenge of designing a construct for the repair of focal cartilage defects such that it mimics the mechanical properties of and can integrate with native cartilage. Herein we describe a novel construct consisting of a non-degradable poly-vinyl alcohol (PVA) scaffold to provide long-term mechanical stability, interconnected pores to allow for the infiltration of chondrocytes, and polylactic glycolic acid (PLGA) microspheres for the incorporation of growth factors to enhance cellular migration. The objective of this study was to characterize the morphological features and mechanical properties of our porous PVA-PLGA construct as a function of PLGA content. Varying the PLGA content was found to have a significant effect on the morphological features of the construct. As PLGA content increased from 10% to 75%, samples exhibited a 6-fold increase in average percentage porosity, an increase in average microsphere diameter from 8 to 34 mu m and an increase in average pore diameter from 29 to 111 mu m. The effect of PLGA content on aggregate modulus and permeability was less profound. Our findings suggest that that morphology of the construct can be tailored to optimize cellular infiltration and the dynamic mechanical response.
The experiments herein presented were conducted at the Hospital for Special Surgery.
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Details
- Title
- Semi-degradable scaffold for articular cartilage replacement
- Creators
- Devon C. Charlton - Hospital for Special SurgeryMargaret G. E. Peterson - Hosp Special Surg, Lab Funct Tissue Engn, New York, NY 10021 USAKara Spiller - Drexel UniversityAnthony Lowman - Drexel Univ, Dept Chem Engn, Philadelphia, PA 19104 USAPeter A. Torzilli - Hosp Special Surg, Lab Funct Tissue Engn, New York, NY 10021 USASuzanne A. Maher - Hosp Special Surg, Lab Funct Tissue Engn, New York, NY 10021 USA
- Publication Details
- Tissue engineering. Part A, v 14(1), pp 207-213
- Publisher
- Mary Ann Liebert, Inc
- Number of pages
- 7
- Grant note
- C06 RR012538; C06-RR12538-01 / NCRR NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) P30 AR046121-08; P30 AR046121; AR046121 / NIAMS NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS) C06RR012538 / NATIONAL CENTER FOR RESEARCH RESOURCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) P30AR046121 / NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000253960900020
- Scopus ID
- 2-s2.0-38349153249
- Other Identifier
- 991019168258304721
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Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Cell & Tissue Engineering
- Cell Biology
- Engineering, Biomedical
- Materials Science, Biomaterials