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Published, Version of Record (VoR)CC BY V4.0, Open
Journal article
Sensorimotor transformation underlying odor-modulated locomotion in walking Drosophila
Nature communications, v 14(1), 6818
26 Oct 2023
PMID: 37884581
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Most real-world behaviors – such as odor-guided locomotion - are performed with incomplete information. Activity in olfactory receptor neuron (ORN) classes provides information about odor identity but not the location of its source. In this study, we investigate the sensorimotor transformation that relates ORN activation to locomotion changes in
Drosophila
by optogenetically activating different combinations of ORN classes and measuring the resulting changes in locomotion. Three features describe this sensorimotor transformation: First, locomotion depends on both the instantaneous firing frequency (
f
) and its change (
df
); the two together serve as a short-term memory that allows the fly to adapt its motor program to sensory context automatically. Second, the mapping between (
f, df
) and locomotor parameters such as speed or curvature is distinct for each pattern of activated ORNs. Finally, the sensorimotor mapping changes with time after odor exposure, allowing information integration over a longer timescale.
Animals find and stay close to resources by altering their locomotion in response to odors that signal resources. Here the authors identify, using Drosophila locomotion in response to odor, a simple strategy that adapts its motor program to sensory context automatically.
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Details
- Title
- Sensorimotor transformation underlying odor-modulated locomotion in walking Drosophila
- Creators
- Liangyu Tao - Drexel UniversitySamuel P. Wechsler - Drexel UniversityVikas Bhandawat - Drexel University
- Publication Details
- Nature communications, v 14(1), 6818
- Publisher
- Nature Publishing Group UK
- Grant note
- ; RO1DC015827 / ; RO1NS097881; F31NS120835; NIH F31NS120835-02 / ; IOS-1652647 / ;
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:001091358000003
- Scopus ID
- 2-s2.0-85174930593
- Other Identifier
- 991021480177104721
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