Journal article
Sensory Dysfunction, Microbial Infections, and Host Responses in Alzheimer's Disease
The Journal of infectious diseases, v 230(Supplement_2), pp S150-S164
10 Sep 2024
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Abstract Sensory functions of organs of the head and neck allow humans to interact with the environment and establish social bonds. With aging, smell, taste, vision, and hearing decline. Evidence suggests that accelerated impairment in sensory abilities can reflect a shift from healthy to pathological aging, including the development of Alzheimer's disease (AD) and other neurological disorders. While the drivers of early sensory alteration in AD are not elucidated, insults such as trauma and infections can affect sensory function. Herein, we review the involvement of the major head and neck sensory systems in AD, with emphasis on microbes exploiting sensory pathways to enter the brain (the “gateway” hypothesis) and the potential feedback loop by which sensory function may be impacted by central nervous system infection. We emphasize detection of sensory changes as first-line surveillance in senior adults to identify and remove potential insults, like microbial infections, that could precipitate brain pathology.
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Details
- Title
- Sensory Dysfunction, Microbial Infections, and Host Responses in Alzheimer's Disease
- Creators
- Praveen Bathini (Corresponding Author) - Brigham and Women's HospitalEmanuele BraiBrian J Balin - Philadelphia College of Osteopathic MedicineLynn Bimler - Baylor College of MedicineDavid B Corry - Baylor College of MedicineDavangere P Devanand - Alzheimer’s Disease Neuroimaging InitiativeRichard L Doty - University of PennsylvaniaGarth D Ehrlich - Drexel UniversityWilliam A Eimer - Massachusetts General HospitalTamas Fulop - Université de SherbrookeDavid L Hahn - Alzheimer’s Disease Neuroimaging InitiativeChristine J Hammond - Alzheimer’s Disease Neuroimaging InitiativeJoseph Infanti - Alzheimer’s Disease Neuroimaging InitiativeRuth Itzhaki - University of OxfordRichard Lathe - Alzheimer’s Disease Neuroimaging InitiativeChristopher Scott Little - Alzheimer’s Disease Neuroimaging InitiativeRima McLeod - University of ChicagoShima T Moein - Alzheimer’s Disease Neuroimaging InitiativeAmy R Nelson - University of South AlabamaGeorge Perry - Alzheimer’s Disease Neuroimaging InitiativeOr A Shemesh - Alzheimer’s Disease Neuroimaging InitiativeRudolph E Tanzi - Massachusetts General HospitalWilmore C Webley - Alzheimer’s Disease Neuroimaging InitiativeNikki M Schultek - Alzheimer’s Disease Neuroimaging InitiativeLavinia Alberi Auber
- Publication Details
- The Journal of infectious diseases, v 230(Supplement_2), pp S150-S164
- Publisher
- Oxford University Press; CARY
- Number of pages
- 15
- Grant note
- National Institute on Aging, National Institutes of Health: R00AG058780
This work was supported by the Susan and Richard Kiphart family; the Dominique Cornwell and Peter Mann Family Foundation; and The Rayni Foundation, Inc. on behalf of the Rodriguex Family (to R. Mc.) (grant number R00AG058780, National Institute on Aging, National Institutes of Health to A. R. N.).
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:001309698500006
- Scopus ID
- 2-s2.0-85204013304
- Other Identifier
- 991021903361904721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Immunology
- Infectious Diseases
- Microbiology