Journal article
Sensory processing in the Drosophila antennal lobe increases reliability and separability of ensemble odor representations
Nature neuroscience, v 10(11), pp 1474-1482
Nov 2007
PMID: 17922008
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Here we describe several fundamental principles of olfactory processing in the Drosophila melanogaster antennal lobe (the analog of the vertebrate olfactory bulb), through the systematic analysis of input and output spike trains of seven identified glomeruli. Repeated presentations of the same odor elicit more reproducible responses in second-order projection neurons (PNs) than in their presynaptic olfactory receptor neurons (ORNs). PN responses rise and accommodate rapidly, emphasizing odor onset. Furthermore, weak ORN inputs are amplified in the PN layer but strong inputs are not. This nonlinear transformation broadens PN tuning and produces more uniform distances between odor representations in PN coding space. In addition, portions of the odor response profile of a PN are not systematically related to their direct ORN inputs, which probably indicates the presence of lateral connections between glomeruli. Finally, we show that a linear discriminator classifies odors more accurately using PN spike trains than using an equivalent number of ORN spike trains.
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Details
- Title
- Sensory processing in the Drosophila antennal lobe increases reliability and separability of ensemble odor representations
- Creators
- Vikas Bhandawat - Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USAShawn R OlsenNathan W GouwensMichelle L SchliefRachel I Wilson
- Publication Details
- Nature neuroscience, v 10(11), pp 1474-1482
- Publisher
- Springer Nature; United States
- Grant note
- 1F32DC008471-01A1 / NIDCD NIH HHS R01 DC008174-02 / NIDCD NIH HHS F32 DC008741 / NIDCD NIH HHS R01 DC008174 / NIDCD NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000250508400026
- Scopus ID
- 2-s2.0-35548945012
- Other Identifier
- 991014878017804721
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- Web of Science research areas
- Neurosciences