Journal article
Separation of major prostaglandins, leukotrienes, and monoHETEs by high performance liquid chromatography
Journal of immunological methods, v 64(3), pp 335-343
25 Nov 1983
PMID: 6321597
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
A procedure using high performance liquid chromatography (HPLC) is described for the separation of major primary cyclooxygenase metabolites (prostacyclin metabolite-6ketoPGF
1α, thromboxane B
2, and prostaglandins F
2α, E
2, and D
2), leukotrienes (C
4, B
4, and D
4), monohydroxyeicosatetraenoic acids (15-, 11-, 12-, and 5HETEs), and free arachidonic acid. It is therefore possible to quantitate major arachidonic acid metabolites by a single chromatographic procedure. Using this technique we have determined that a major arachidonic acid metabolite of human lung macrophages co-elutes with leukotriene B
4.
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Details
- Title
- Separation of major prostaglandins, leukotrienes, and monoHETEs by high performance liquid chromatography
- Creators
- Stephen P. Peters - Good Samaritan HospitalEdward S. Schulman - Johns Hopkins UniversityMark C. Liu - Good Samaritan HospitalEdward C. Hayes - Good Samaritan HospitalLawrence M. Lichtenstein - Good Samaritan Hospital
- Publication Details
- Journal of immunological methods, v 64(3), pp 335-343
- Publisher
- Elsevier
- Number of pages
- 9
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pulmonary, Critical Care, and Sleep (Medicine)
- Web of Science ID
- WOS:A1983RV87900009
- Scopus ID
- 2-s2.0-0021076155
- Other Identifier
- 991021935001104721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- Web of Science research areas
- Biochemical Research Methods
- Immunology