Journal article
Septin Mutations in Human Cancers
Frontiers in cell and developmental biology, v 4, pp 122-122
2016
PMID: 27882315
Abstract
Septins are GTP-binding proteins that are evolutionarily and structurally related to the
oncogenes. Septin expression levels are altered in many cancers and new advances point to how abnormal septin expression may contribute to the progression of cancer. In contrast to the
GTPases, which are frequently mutated and actively promote tumorigenesis, little is known about the occurrence and role of septin mutations in human cancers. Here, we review septin missense mutations that are currently in the Catalog of Somatic Mutations in Cancer (COSMIC) database. The majority of septin mutations occur in tumors of the large intestine, skin, endometrium and stomach. Over 25% of the annotated mutations in SEPT2, SEPT4, and SEPT9 belong to large intestine tumors. From all septins, SEPT9 and SEPT14 exhibit the highest mutation frequencies in skin, stomach and large intestine cancers. While septin mutations occur with frequencies lower than 3%, recurring mutations in several invariant and highly conserved amino acids are found across different septin paralogs and tumor types. Interestingly, a significant number of these mutations occur in the GTP-binding pocket and septin dimerization interfaces. Future studies may determine how these somatic mutations affect septin structure and function, whether they contribute to the progression of specific cancers and if they could serve as tumor-specific biomarkers.
Metrics
Details
- Title
- Septin Mutations in Human Cancers
- Creators
- Dimitrios Angelis - Department of Biology, Drexel University Philadelphia, PA, USAElias T Spiliotis - Department of Biology, Drexel University Philadelphia, PA, USA
- Publication Details
- Frontiers in cell and developmental biology, v 4, pp 122-122
- Publisher
- Frontiers; Switzerland
- Grant note
- R01 GM097664 / NIGMS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology; Pediatrics
- Web of Science ID
- WOS:000455229700122
- Scopus ID
- 2-s2.0-85037692681
- Other Identifier
- 991014878035604721
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Cell Biology
- Developmental Biology