Journal article
Septin functions in organ system physiology and pathology
Biological chemistry, v 395(2), pp 123-141
Feb 2014
PMID: 24114910
Abstract
Human septins comprise a family of 13 genes that encode for >30 protein isoforms with ubiquitous and tissue-specific expressions. Septins are GTP-binding proteins that assemble into higher-order oligomers and filamentous polymers, which associate with cell membranes and the cytoskeleton. In the last decade, much progress has been made in understanding the biochemical properties and cell biological functions of septins. In parallel, a growing number of studies show that septins play important roles for the development and physiology of specific tissues and organs. Here, we review the expression and function of septins in the cardiovascular, immune, nervous, urinary, digestive, respiratory, endocrine, reproductive, and integumentary organ systems. Furthermore, we discuss how the tissue-specific functions of septins relate to the pathology of human diseases that arise from aberrations in septin expression.
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Details
- Title
- Septin functions in organ system physiology and pathology
- Creators
- Lee Dolat - Department of Biology, Drexel University, 3245 Chestnut Street, Philadelphia, PA 19104, USAQicong Hu - Department of Biology, Stanford University, Stanford, CA 94305, USAElias T Spiliotis - Department of Biology, Drexel University, 3245 Chestnut Street, Philadelphia, PA 19104, USA
- Publication Details
- Biological chemistry, v 395(2), pp 123-141
- Publisher
- De Gruyter
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology
- Web of Science ID
- WOS:000329820300002
- Scopus ID
- 2-s2.0-84893730542
- Other Identifier
- 991014877690004721
InCites Highlights
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology