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Journal article
Sequence of bronchoalveolar lavage and histopathologic findings in rat lungs early in inhalation asbestos exposure
Journal of toxicology and environmental health, v 20(1-2), pp 147-161
01 Jan 1987
PMID: 3806701
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Abstract
To assess the early cellular inflammatory response of the lungs, 7 rats per group were exposed nose-only to 13 mg/m
3
of chrysotile asbestos, 7 h/day for 2, 4, or 6 wk. Lung histopathology and bronchoalveolar lavage (BAL) were analyzed. In exposed animals, dose-related bronchiolitis and fibrosis were found that were not seen in control rats (p < 0.001). In exposed rats, total BAL cells were increased six- to sevenfold over matched controls, and more cells were retrieved with longer exposure (p < 0.001). In the BAL, counts of macrophages, lymphocytes, and polymorphonuclear cells (PMNs) were each elevated in the exposed rats (each p < 0.001). PMNs seen histologically and in the BAL may be related to the time period examined. PMNs and lymphocytes observed throughout this 6-wk study support the idea that these cells may have an important role in the early events of asbestos lung injury.
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Details
- Title
- Sequence of bronchoalveolar lavage and histopathologic findings in rat lungs early in inhalation asbestos exposure
- Creators
- Cecilia M. Smith - University of California San Diego Medical CenterSharon Batcher - University of California SystemAntonino Catanzaro - University of California SystemJerrold L. Abraham - SUNY Upstate Medical UniversityRobert Phalen - University of California, IrvineUniv. of California, San Diego
- Publication Details
- Journal of toxicology and environmental health, v 20(1-2), pp 147-161
- Publisher
- Taylor & Francis Group
- Number of pages
- 15
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Medicine (Graduate)
- Web of Science ID
- WOS:A1987F855900012
- Scopus ID
- 2-s2.0-0023136659
- Other Identifier
- 991021961014404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Environmental Sciences
- Public, Environmental & Occupational Health
- Toxicology