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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Sequential Drug Delivery to Modulate Macrophage Behavior and Enhance Implant Integration
Advanced drug delivery reviews, v 149-150
01 Jan 2019
PMID: 31103451
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Macrophages are major upstream regulators of the inflammatory response to implanted biomaterials. Sequential functions of distinct macrophage phenotypes are essential to the normal tissue repair process, which ideally results in vascularization and integration of implants. Improper timing of M1 or M2 macrophage activation results in dysfunctional healing in the form of chronic inflammation or fibrous encapsulation of the implant. Thus, biphasic drug delivery systems that modulate macrophage behavior are an appealing approach to promoting implant integration. In this review, we describe the timing and roles of macrophage phenotypes in healing, then highlight current drug delivery systems designed to sequentially modulate macrophage behavior.
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Details
- Title
- Sequential Drug Delivery to Modulate Macrophage Behavior and Enhance Implant Integration
- Creators
- Erin M. O’Brien - Biomaterials and Regenerative Medicine Laboratory, School of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, PA, United StatesGregory E. Risser - Drexel UniversityKara L. Spiller - Drexel University
- Publication Details
- Advanced drug delivery reviews, v 149-150
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000503094100006
- Scopus ID
- 2-s2.0-85066091849
- Other Identifier
- 991019169164304721
UN Sustainable Development Goals (SDGs)
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Pharmacology & Pharmacy