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Published, Version of Record (VoR)CC BY V4.0, Open
Journal article
Sequential events during the quiescence to proliferation transition establish patterns of follicle cell differentiation in the Drosophila ovary
Biology open, v 12(1), 059625
01 Jan 2023
PMID: 36524613
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Stem cells cycle between periods of quiescence and proliferation to promote tissue health. In Drosophila ovaries, quiescence to proliferation transitions of follicle stem cells (FSCs) are exquisitely feeding-dependent. Here, we demonstrate feeding-dependent induction of follicle cell differentiation markers, eyes absent (Eya) and castor (Cas) in FSCs, a patterning process that does not depend on proliferation induction. Instead, FSCs extend micron-scale cytoplasmic projections that dictate Eya-Cas patterning. We identify still life and sickie as necessary and sufficient for FSC projection growth and Eya-Cas induction. Our results suggest that sequential, interdependent events establish long-term differentiation patterns in follicle cell precursors, independently of FSC proliferation induction.
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Details
- Title
- Sequential events during the quiescence to proliferation transition establish patterns of follicle cell differentiation in the Drosophila ovary
- Creators
- Eric H. Lee - Fox Chase Cancer CenterDaniel Zinshteyn - Fox Chase Cancer CenterFred Miglo - Fox Chase Cancer CenterMelissa Q. Wang - Fox Chase Cancer CenterJessica Reinach - Fox Chase Cancer CenterCindy M. Chau - Fox Chase Cancer CenterJoseph M. Grosstephan - Fox Chase Cancer CenterIliana Correa - Fox Chase Cancer CenterKelly Costa - Fox Chase Cancer CenterAlberto Vargas - Fox Chase Cancer CenterAminah Johnson - Fox Chase Cancer CenterSheila M. Longo - Fox Chase Canc Ctr, Mol Therapeut Program, Philadelphia, PA 19111 USAJennifer I. Alexander - Huntingdon CollegeAlana M. O'Reilly - Drexel University, College of Medicine
- Publication Details
- Biology open, v 12(1), 059625
- Publisher
- Company Biologists Ltd
- Number of pages
- 14
- Grant note
- Fox Chase Cancer Center Grateful Kidney Cancer Patient fund at FCCC Bucks County Board of Associates R01 HD065800; R21 HD105295; T32 CA009035; P30 CA06927 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine
- Web of Science ID
- WOS:000933145900007
- Scopus ID
- 2-s2.0-85187918375
- Other Identifier
- 991021861202904721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biology