Journal article
Serial Analysis of Magnetization-Transfer Histograms and Expanded Disability Status Scale Scores in Patients with Relapsing-Remitting Multiple Sclerosis
American journal of neuroradiology : AJNR, v 20(10), pp 1946-1950
01 Nov 1999
PMID: 10588123
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
BACKGROUND AND PURPOSE:
Magnetization transfer ratio histogram peak height (MTR-HPH) has been shown to correlate with macroscopic and microscopic brain disease in patients with multiple sclerosis (MS). We studied the changes in MTR-HPH and in Kurtzke's Expanded Disability Status Scale (EDSS) scores over time in a group of patients with relapsing-remitting MS.
METHODS:
Twenty adult patients with relapsing-remitting MS (four men and 16 women) were followed up for a period of 334 to 1313 days. In all, 86 MR imaging studies of the brain were obtained, and MTR-HPH was calculated for each MR examination by using a semiautomated technique. Changes in MTR-HPH were compared between patients over the study's duration. A neurologist specialized in the care of MS patients assessed the EDSS score for each patient as a measure of clinical disability.
RESULTS:
Serial MR data showed a subtle but significant decline in MTR-HPH with time. No significant changes in EDSS scores were noted over the same period.
CONCLUSION:
Patients with relapsing-remitting MS have a significant progressive decline in normalized MTR-HPH, which is independent of EDSS score. MTR-HPH measurements can be used to monitor subclinical disease in patients with relapsing-remitting MS over a short time frame of 1 to 4 years. This parameter might be applied in future therapeutic trials to assess its usefulness.
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Details
- Title
- Serial Analysis of Magnetization-Transfer Histograms and Expanded Disability Status Scale Scores in Patients with Relapsing-Remitting Multiple Sclerosis
- Creators
- Upen J. PatelRobert I. GrossmanMichael D. PhillipsJayaram K. UdupaJoseph C. McGowanYukio MikiLuogang WeiMarcia PolanskyMark A. van BuchemDennis Kolson
- Publication Details
- American journal of neuroradiology : AJNR, v 20(10), pp 1946-1950
- Publisher
- American Society of Neuroradiology
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- [Retired Faculty]
- Web of Science ID
- WOS:000083887500030
- Scopus ID
- 2-s2.0-0032716096
- Other Identifier
- 991019168505804721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Clinical Neurology
- Neuroimaging
- Radiology, Nuclear Medicine & Medical Imaging