Logo image
Back
Serotonergic function and self-injurious behavior in personality disorder patients
Journal article   Peer reviewed

Serotonergic function and self-injurious behavior in personality disorder patients

Antonia S. New, Robert L. Trestman, Vivian Mitropoulou, Deana S. Benishay, Emil Coccaro, Jeremy Silverman, Larry J. Siever and Jan F Silverman
Psychiatry research, v 69(1), pp 17-26
1997
DOI: https://doi.org/10.1016/S0165-1781(96)02784-9
PMID: 9080541
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

Gender Serotonin Suicide
Self-directed aggression, whether in the form of non-suicidal self-mutilation or suicidal behavior, is a prominent feature of personality disorders. We hypothesized that self-injurious behavior, like suicidal behavior, represents a form of self-directed aggression, and may, like suicidal behavior and impulsive aggression, be associated with a decrease in central serotonin function in personality disorder patients. Ninety-seven patients with DSM-III personal ity disorder underwent d,l-fenfluramine challenge as an assessment of serotonergic activity. Patients with a history of self-mutilation or suicide had blunted prolactin and cortisol responses to d,l-fenfluramine compared to those with neither, and those with both had the most blunted responses to fenfluramine. These data raise the possibility that the central 5-HT abnormality, previously associated with suicidal behavior, may be associated with self-directed violence and not necessarily specifically with suicidal intent.

Metrics

11 Record Views
84 citations in Web of Science
97 citations in Scopus

Details

UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

InCites Highlights

Data related to this publication, from InCites Benchmarking & Analytics tool:

Collaboration types
Domestic collaboration
Web of Science research areas
Psychiatry
Logo image